中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (3): 172-174.doi: 10.12144/zgmfskin202203172

• 病例报告 • 上一篇    下一篇

结节性恶性黑素瘤一例

朱雅婧1,刘于媛1,张锦丽1,黄虹2   

  1. 1云南中医药大学，昆明，650500；
    2云南中医药大学第一附属医院/云南省中医医院，昆明，650021
  • 出版日期:2022-03-15 发布日期:2022-01-05
  • 通讯作者: 黄虹，E-mail：ynswjyx@163.com

Nodular malignant melanoma: a case report

ZHU Yajing1, LIU Yuyuan1, ZHANG Jinli1, HUANG Hong2   

  1. 1 Yunnan University of Traditional Chinese Medicine, Kunming 650500, China;
    2 The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine/Yunnan Hospital of Traditional Chinese Medicine, Kunming 650021, China
  • Online:2022-03-15 Published:2022-01-05
  • Contact: HUANG Hong, E-mail:ynswjyx@163.com

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摘要： 结节性黑素瘤是一种处于垂直生长期的恶性黑素瘤亚型，占所有黑素瘤的10%～15%。皮损可为隆起的丘疹或斑块，偶尔呈息肉样，可发生于身体的任何部位。本患者，女，30岁。左上臂伸侧暗红色结节5年余，加重1年。皮损组织病理：真皮层见大量肿瘤细胞弥漫性浸润，细胞核大、异形，可见大量核分裂像。免疫组化：MelanA、SOX-10、Ki-67、P53、S-100均为阳性，Clark分级，IV级。诊断：结节性恶性黑素瘤。

关键词: 恶性黑素瘤, 结节性恶性黑素瘤

Abstract: Nodular melanoma is the aggressive subtype of melanoma, with rapid growth rate and metastatic potential, which accounts for 10%-15% of all melanomas. The tumor may be nodular or polypoid (polypoid melanoma). The patient was a 30-year-old female with a dark red nodule on the extension side of the left upper arm for more than 5 years, which became worse for 1 year. Histopathologic examination showed a large number of diffuse infiltration of tumor cells in the dermis, with large and abnormal nuclei, and a large number of mitotic figures. Immunohistochemistry showed MelanA, SOX-10, Ki-67, P53, S-100 are positive, at IV grade of Clark classification. The diagnosis of nodular malignant melanoma was made.

Key words: malignant melanoma, nodular malignant melanoma