中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (4): 214-216.doi: 10.12144/zgmfskin202204214

• 论著 • 上一篇    下一篇

梅毒血清固定患者神经梅毒发生情况及相关因素分析

陈怀忠,谢俭,李伟,李世慎,陈娜娜,朱邦勇   

  1. 广西壮族自治区皮肤病防治研究所，广西南宁，530003
  • 出版日期:2022-04-15 发布日期:2022-02-10
  • 通讯作者: 陈怀忠，E-mail: 745461891@qq.com

Analysis of the incidence of neurosyphilis and related factors in patients with syphilis serofast

CHEN Huaizhong, XIE Jian, LI Wei, LI Shishen, CHEN Nana, ZHU Bangyong   

  1. Institute of Dermatology, Guangxi Zhuang Autonomous Region, Nanning 530003, China
  • Online:2022-04-15 Published:2022-02-10
  • Contact: CHEN Huaizhong,E-mail: 745461891@qq.com

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摘要： 目的：了解规范治疗后梅毒血清固定患者中神经梅毒发生情况，并探讨其相关影响因素。方法：收集2013年1月至2021年6月在我院行腰穿术的梅毒血清固定患者临床资料进行回顾性分析，采用多因素logistic回归模型分析神经梅毒发生的相关因素，运用ROC曲线评价血清初始TRUST滴度对神经梅毒的诊断价值。结果：共分析101例患者，其中神经梅毒组30例（男26例，女4例）, 非神经梅毒组71例（男25例，女46例）。男性（OR=9.210，95% CI 2.450~34.620，P=0.001）、血清初始TRUST滴度≥1∶16（OR=1.808，95% CI 1.143~2.858，P=0.011）与神经梅毒的发病有关。血清TRUST初始滴度预测神经梅毒ROC曲线下面积为0.708(P=0.001)，约登指数最大值0.407。结论：男性、血清初始TRUST滴度≥1∶16是神经梅毒发生的危险因素，但根据ROC曲线下面积，血清初始TRUST滴度对神经梅毒的诊断价值较低。

关键词: 血清固定；神经梅毒, TRUST滴度；影响因素；logistic回归

Abstract: Objective: To investigate the incidence of neurosyphilis in patients with syphilis serofast after standard treatment, and analyze the related factors. Methods:The clinical data of patients with syphilis serofast whom performed lumbar puncture from January 2013 to June 2021 was retrospectively reviewed. Logistic regression model was used to analyze the related factors of neurosyphilis, and the Receiver operating curve (ROC) was used to evaluate the diagnostic value of initial serum TRUST titer for neurosyphilis. Results: 101 patients were collected including 30 neurosyphilis patients (26 males and 4 females) and 71 syphilis patients (25 males and 46 females).  Male sex (OR=9.210，95%CI 2.450-34.620，P=0.001) and initial serum TRUST titer （OR=1.808，95%CI 1.143-2.858，P=0.011）were significantly associated with neurosyphilis. The area under the ROC curve (AUC) was 0.708 (P=0.001), Youden's index 0.407. Conclusion: The Male sex，high level of Serum TRUST titer are the risk factors for neurosyphilis, but the value of initial TRUST titer in the diagnosis of neurosyphilis is low according to the AUC.

Key words: syphilis serofast, neurosyphilis, TRUST titers, related factors, logistic regression