中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (6): 398-400.doi: 10.12144/zgmfskin202206398

• 病例报告 • 上一篇    下一篇

原发性皮肤CD4+小/中T细胞淋巴组织增生性疾病一例

刘小琴,熊心猜,李凤香,杨晓龙   

  1. 川北医学院附属医院皮肤科，四川南充，637000
  • 出版日期:2022-06-15 发布日期:2022-04-14
  • 通讯作者: 熊心猜，E－mail: xiongxincai＠163.com

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder：a case report

LIU Xiaoqin, XIONG Xincai, LI Fengxiang, YANG Xiaolong   

  1. Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000,China
  • Online:2022-06-15 Published:2022-04-14
  • Contact: XIONG Xincai, E-mail: xiongxincai＠163.com

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摘要： 患者，女，55岁。右耳后结节半年。皮损组织病理示：真皮组织内、皮肤附属器周围见大量中等大小淋巴细胞浸润，细胞轻度异型，背景可见小淋巴细胞和组织细胞。免疫组化提示：CD4（+）、CD8（+，少数细胞）、CD20（+）、CD3（+）、CD2（+）、CD79a散在（+）、CD5（+）、CD7（+）、Ki-67（+，＜5%）。TCRG基因重排检测在目标条带范围内查见克隆性扩增峰。诊断：原发性皮肤CD4+小/中T淋巴组织增生性疾病,予以局部手术切除。

关键词: 淋巴组织增生性疾病, 原发性皮肤淋巴瘤, T细胞淋巴瘤, CD4+

Abstract: A 55-year-old female presented with nodule behind the right ear for half a year. Skin biopsy revealed that a large number of medium-size lymphocytes infiltrated in the dermis and around the skin appendages, with mild atypia, and small lymphocytes and histological cells were seen. Immunohistochemistry examination showed that CD4 (+), CD8 (+, a few cells), CD2 (+), CD20 (+), CD3 (+), CD79a scattered (+), CD5 (+), CD7 (+), Ki-67 (+, < 5%). The clonal amplification peak was found in the target band by TCRG gene rearrangement detection. The diagnosis of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder was made.

Key words: lymphoproliferative disorder, primary cutaneous lymphoma, T-cell lymphoma, CD4+