中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (6): 372-374.doi: 10.12144/zgmfskin201906372

• 综述 • 上一篇    下一篇

细胞凋亡在皮肤T细胞淋巴瘤发病与治疗中的作用

朱小美  孙建   

  1. 中国医学科学院北京协和医学院皮肤病研究所，江苏南京，210042
  • 出版日期:2019-06-15 发布日期:2019-06-10
  • 通讯作者: 孙建方，E-mail：fangmin5758@aliyun.com

Apoptosis in the pathogenesis and treatment of Cutaneous T Cell Lymphomas

ZHU Xiaomei, SUN Jianfang   

  1. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2019-06-15 Published:2019-06-10
  • Contact: Sun Jianfang, Email：fangmin5758@aliyun.com

PDF (PC)

153

摘要： 皮肤T细胞淋巴瘤是一组原发于皮肤的非霍奇金淋巴瘤，蕈样肉芽肿和Sézary综合征占绝大部分。肿瘤细胞早期有丝分裂指数较低及对细胞毒性药物的治疗反应差，提示细胞凋亡缺陷在其发病机制中起重要作用。本文以蕈样肉芽肿和Sézary综合征为重点，对凋亡在皮肤T细胞淋巴瘤发病与治疗中的作用进行了综述。

关键词: 皮肤T细胞淋巴瘤, 细胞凋亡, 发病机制, 治疗

Abstract: Cutaneous T cell lymphoma is a group of heterogeneous non-Hodgkin lymphomas that represents malignancies of skin-homing T cells. Clinically majority are mycosis fungoides and Sézary syndrome. The low mitosis index and resistance to treatment with genotoxic agents suggest that defective apoptosis signaling plays a role in the pathogenesis of CTCL. In this report, the role of apoptosis in the pathogenesis and treatment of CTCL is reviewed mainly focusing on mycosis fungoides and Sezary syndrome.

Key words: cutaneous T cell lymphoma, apoptosis, pathogenesis, treatment