中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (4): 265-268.doi: 10.12144/zgmfskin202304265

• 临床研究 • 上一篇    下一篇

糖皮质激素联合TNF-α抑制剂成功治疗疱疹样脓疱病二例

黎龙珊,李汀影,张小超,刘冬先   

  1. 华中科技大学同济医学院附属同济医院皮肤病与性病科，武汉，430030
  • 出版日期:2023-04-15 发布日期:2023-03-27

Two cases of impetigo herpetiformis successfully treated by steroid combined with TNF-α inhibitors

LI Longshan, LI Tingying, ZHANG Xiaochao, LIU Dongxian   

  1. Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Online:2023-04-15 Published:2023-03-27

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摘要： 妊娠期疱疹样脓疱病的治疗仍是一个比较棘手的问题，治疗的主要难点在于妊娠用药的局限性。口服激素、环孢素是推荐治疗IH的一线用药方案，在其他药物使用疗效不佳时可谨慎使用生物制剂。既往有使用TNF-α成功治疗IH的病例报道，本文报道的2例疱疹样脓疱病在常规治疗病情控制不佳时,使用了不同的TNF-α拮抗剂，患者的皮损均在分娩之前得到了控制，并分娩出健康新生儿，为IH的治疗提供参考，但更加安全、系统的治疗方案仍需要更多的病例去总结。

关键词: 疱疹样脓疱病, IL-36RN, TNF-α抑制剂

Abstract: The treatment of impetigo herpetiformis (IH) during pregnancy remains a challenge and the main difficulty in treatment lies in the limitations of the medications used in pregnancy. Glucocorticoids and cyclosporine are the recommended first-line regimens for the treatment of IH. Biologics may be used cautiously when other drugs are ineffective. It has been reported that IH was successfully treated with TNF-α in the previous literature reports. In this paper, two cases of IH were treated with TNF-α antagonists when conventional treatment failed. Both patients' skin lesions were controlled before delivery, and healthy neonates were delivered, which provided a reference for the treatment of IH. However, more cases are needed for a safer and more systematic treatment plan.

Key words: impetigo herpetiformis, IL-36RN, TNF-α inhibitors