中国麻风皮肤病杂志 ›› 2023, Vol. 39 ›› Issue (9): 688-692.doi: 10.12144/zgmfskin202309688

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IL-33参与2型炎症瘙痒的神经免疫机制研究进展

周灵萱1,赵洋2,袁晓辉1,徐哲2，3,刘玲玲1,汪旸1,赵嘉惠1   

  1. 1北京大学第一医院皮肤性病科＆国家皮肤与免疫疾病临床医学研究中心＆皮肤病分子诊断北京市重点实验室＆国家药品监督管理局化妆品质量控制与评价重点实验室，北京，100034；
    2北京市顺义区妇幼保健院，北京儿童医院顺义妇儿医院，北京，101300；
    3国家儿童医学中心，首都医科大学附属北京儿童医院皮肤科，北京，100045
  • 出版日期:2023-09-15 发布日期:2023-09-05

Neuroimmune mechanisms of IL-33 involved in type 2 inflammatory pruritus

ZHOU Lingxuan1, ZHAO Yang2, YUAN Xiaohui1, XU Zhe2，3, LIU Lingling1, WANG Yang1, ZHAO Jiahui1   

  1. 1 Department of Dermatology, Peking University First Hospital ＆ Beijing Key Laboratory of Molecular Diagnosis on Dermatoses ＆ National Clinical Research Center for Skin and Immune Disease ＆ NMPA Key Laboratory for Quality Control and Evaluation of Cosmetics, Beijing 100034, China;
    2 Shunyi Maternal and Children's Hospital of Beijing Children's Hospital, Beijing 101300，China;
    3 Department of Dermatology, Beijing Children's Hospital, Capital Medical University ＆ National Center for Children's Health, Beijing 100045,China
  • Online:2023-09-15 Published:2023-09-05

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摘要： IL-33是白细胞介素1家族来源的核细胞因子，通过其受体作用于多种细胞，如肥大细胞、2型固有淋巴细胞、嗜碱性粒细胞，是2型免疫反应发生及维持的重要细胞因子之一。近年来研究表明，IL-33激活外周神经系统参与瘙痒信号的传递。本文回顾了IL-33介导受体激活的信号转导机制/2型炎症皮肤病中IL-33参与瘙痒的神经免疫机制及IL-33靶向药物研究进展。

关键词: IL-33, 瘙痒, 2型炎症, 神经免疫

Abstract: IL-33 is a nuclear cytokine of the IL-1 family, which acts on a variety of cells through combination its receptors, such as mast cells, innate lymphocytes type 2, basophils, etc. . It is one of the important cytokines in the development and maintenance of type 2 immune responses. Recent studies have shown that IL-33 is involved in pruritic signaling through activating the peripheral nervous system. This paper focuses on the signal transduction mechanism after the activation of interleukin 33 receptor, and elaborates the neuroimmune mechanism of IL-33 involved in pruritus in type 2 inflammatory skin diseases. We also review the advances of drug research targeting IL-33.

Key words: interleukin-33, pruritus, type 2 inflammation, neuroimmunity