中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (5): 358-360.doi: 10.12144/zgmfskin202505358

• 病例报告 • 上一篇    下一篇

原发皮肤CD4+小/中T细胞淋巴组织增殖性疾病一例

戴景欣,任新新,张玉丽,孟宪敏   

  1. 聊城市人民医院皮肤科，山东聊城，252000
  • 出版日期:2025-05-15 发布日期:2025-05-15

Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder: a case report

DAI Jingxin, REN Xinxin, ZHANG Yuli, MENG Xianmin   

  1. Department of Dermatology, Liaocheng People's Hospital, Liaocheng 252000, China
  • Online:2025-05-15 Published:2025-05-15

PDF (PC)

8

摘要： 患者,男，60岁，右胸红色斑块2个月。组织病理示表皮大致正常，真皮层中等偏小的淋巴样细胞增生，呈结节状，弥漫分布，浸润皮肤附属器。肿瘤细胞呈小至中等大小，细胞核深染，轻度不规则，核分裂象不明显，散在少量较大细胞。免疫组化示病变细胞 CD3、CD4、CD5弥漫阳性，部分病变细胞 PD-1阳性，Ki-67增殖指数20%。TCR重排阳性。予以手术切除。

关键词: 原发皮肤CD4+小/中T细胞淋巴组织增生性疾病

Abstract: A 60-year-old man presented with red plaque on the right chest for 2 months. Histopathology showed that the epidermis was almost normal, and the proliferation of small to medium lymphoid cell in dermis, with infiltrating skin appendages. The tumor cells were small to medium in size, the nuclei were hyperchromatic and slightly irregular, and mitotic figures were not obvious, and a few large cells were scattered. Immunohistochemistry showed that the lesion cells were diffusely positive for CD3, CD4 and CD5, and some were positive for PD-1, the positive staining rate for Ki-67 was 20%, T-cell receptor gene rearrangement showed positive result. A diagnosis of primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder was made. Surgical resection was performed.

Key words: primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder