中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (5): 374-376.doi: 10.12144/zgmfskin202505374

• 病例报告 • 上一篇    下一篇

HIV抗体阴性感染马尔尼菲篮状菌一例

孙琳1,2,吴雯婕1,2,笪美红2,蒋浩3,王飞2   

  1. 1东南大学医学院，江苏南京，210003；2南京东南大学附属中大医院皮肤科，江苏南京,210009；3江苏盱眙县人民医院皮肤科，江苏淮安，211799
  • 出版日期:2025-05-15 发布日期:2025-05-15

Talaromyces marneffei infection in a HIV antibody-negative patient: a case report

SUN Lin1,2, WU Wenjie1,2, DA Meihong2, JIANG Hao3, WANG Fei2   

  1. 1 School of Medicine, Southeast University, Nanjing 210003, China; 2 Department of Dermatology, Zhongda Hospital Southeast University, Nanjing 210009, China; 3 Department of Dermatology, Xuyi People's Hospital, Huaian 211799, China
  • Online:2025-05-15 Published:2025-05-15

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摘要： 马尔尼菲篮状菌感染是一种少见深部真菌病，为机会性致病菌，主要存在于HIV阳性等免疫缺陷人群中。本文报道一例HIV抗体阴性患者，临床表现为全身红斑结痂，头皮弥漫性全秃。经皮肤活检、真菌培养、病原微生物高通量基因检测诊断为马尔尼菲篮状菌感染。给予抗真菌治疗，患者皮损逐渐消退，随访3个月无复发。

关键词: 马尔尼菲篮状菌感染, HIV阴性, T细胞免疫缺陷

Abstract: Talaromyces marneffei infection is a rare deep fungal disease and an opportunistic pathogen, mainly infects immunocompromised individuals such as those with HIV positive. We report a case of HIV antibody-negative patient with general erythema and crust, diffuse bald scalp. The patient was diagnosed with Talaromyces marneffei infection by skin biopsy, fungal culture, and next-generation sequencing technology. Antifungal treatment was administered, and the skin lesions of the patient gradually subsided. There was no recurrence during the 3-month follow-up.

Key words: Talaromyces marneffei infection, HIV negative, T cell immunodeficiency