中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (8): 598-601.doi: 10.12144/zgmfskin202508598

• 病例报告 • 上一篇    下一篇

华氏巨球蛋白血症/淋巴浆细胞淋巴瘤合并I型冷球蛋白血症一例

王德丞,彭经,方险峰   

  1. 三峡大学第一临床医学院，宜昌市中心人民医院皮肤科，湖北宜昌，444300
  • 出版日期:2025-08-15 发布日期:2025-08-01

Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia complicated with type I cryoglobulinemia: a case report

WANG Decheng, PENG Jing, FANG Xianfeng   

  1. Department of Dermatology, First Clinical School of Three Gorges University, Yichang Central People's Hospital, Yichang 444300, China
  • Online:2025-08-15 Published:2025-08-01

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摘要： 华氏巨球蛋白血症/淋巴浆细胞淋巴瘤合并I型冷球蛋白血症较罕见，本文报道一例。患者，男，51岁，双下肢、阴囊溃疡伴疼痛8个月。骨髓涂片示骨髓浆细胞浸润，免疫分型示淋巴细胞占有核细胞的32.5%，基因检测提示MYD88L265P基因突变。血清冷球蛋白定性实验阳性，血清蛋白电泳示M蛋白含量增高，血清ELP阳性。予以利妥昔单抗治疗5个月，皮损较前明显好转。

关键词: 皮肤溃疡, 华氏巨球蛋白血症, 淋巴浆细胞淋巴瘤, 冷球蛋白血症

Abstract: Lymphoplasmacytic lymphoma/Waldenstr?m macroglobulinemia combined with type I cryoglobulinemia is rare, and we report a case in this paper. A 51-year-old male presented with ulcers on both lower extremities and the scrotum with pain for 8 months. Bone marrow smear showed infiltration of bone marrow plasma cells. Immunophenotyping showed that lymphocytes accounted for 32.5% of the total nucleated cells. Gene detection showed that MYD88L265P gene mutation. After 5 months of treatment with rituximab, the skin lesions were significantly improved.

Key words: skin ulcer, Waldenstr?m macroglobulinemia, lymphoplasmacytic lymphoma, cryoglobulinemia