中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (8): 610-612.doi: 10.12144/zgmfskin202508610

• 病例报告 • 上一篇    下一篇

结节性痒疹继发坏疽性臁疮一例

张芳,刘佩,南华亮   

  1. 湖北省十堰市太和医院（湖北医药学院附属太和医院）皮肤科，湖北十堰，442000
  • 出版日期:2025-08-15 发布日期:2025-08-01

Prurigo nodularis secondary to ecthyma gangrenosum: a case report

ZHANG Fang, LIU Pei, NAN Hualiang   

  1. Department of Dermatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
  • Online:2025-08-15 Published:2025-08-01

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摘要： 患者，女，57岁。双下肢结节伴痒7个月余，诊断为结节性痒疹，病情反复，1周前自行外用中药擦洗后，局部出现大小不等溃疡，伴疼痛。皮损组织细菌培养提示铜绿假单胞菌生长。组织病理示皮肤溃疡，真皮浅层血管周围炎细胞浸润，给予哌拉西林他唑巴坦抗感染2周及清创换药后好转，1个月后溃疡基本愈合。

关键词: 结节性痒疹, 坏疽性臁疮

Abstract: A 57-year-old female presented, with nodules and itching in both lower limbs for more than 7 months. She was diagnosed with prurigo nodularis and her condition recurred repeatedly. One week ago, after self-administering a traditional Chinese medicine scrub, ulcers of varying sizes appeared locally, accompanied by pain. Bacterial culture of the skin lesion tissue indicated the growth of Pseudomonas aeruginosa. Histopathological examination revealed skin ulcers and perivascular inflammatory cell infiltration in the superficial dermis. The condition improved after 2 weeks of anti-infection treatment with piperacillin-tazobactam, debridementand dressing changes. The ulcers basically healed after 1 month.

Key words: prurigo nodularis, ecthyma gangrenosum