中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (10): 603-606.

• 短篇论著 • 上一篇    下一篇

卤米松乳膏减轻激光治疗鲜红斑痣术后炎症反应的临床研究

钱琳翰，高琳，王莉，殷荣，王刚   

  1. 第四军医大学西京皮肤医院，西安，710032
  • 出版日期:2016-10-15 发布日期:2018-12-17
  • 通讯作者: 王刚，E-mail：xjwgang@fmmu.edu.cn

Topical halometasone reduces acute adverse effects induced by Pulsed Dye Laser for the treatment of port wine stain birthmark

QIAN Linhan，GAO Lin, WANG Li, YIN Rong, WANG Gang   

  1. Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China
  • Online:2016-10-15 Published:2018-12-17
  • Contact: WANG Gang , E-mail：xjwgang@fmmu.edu.cn

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摘要： 目的：评价外用卤米松乳膏减轻脉冲染料激光（PDL）治疗鲜红斑痣（PWS）后急性炎症反应的疗效。方法：PWS患者40例，随机分为两组：试验组PDL治疗后即刻外用卤米松乳膏；对照组PDL治疗后即刻外用凡士林霜。所有受试者均给予单次595 nm PDL治疗，参数为8.0~13.5 J/cm2能量密度，1.5 ms的脉宽，7 mm的光斑。并于术后3、7及30天进行随访。结果：试验组红斑评分为 0.4±0.82，对照组为 0.9±0.91，结痂严重程度实验组为1.15±0.77，对照组为1.65±1.22，实验组与对照组比较差异均有显著性(P＜0.05)。红斑持续天数实验组3.7±8.11/天，显著低于对照组的7.3±10.49/天（P＜0.05）。结论：外用卤米松乳膏可以有效减轻PDL治疗鲜红斑痣的术后急性炎症反应。

关键词: 鲜红斑痣, 脉冲染料激光, 卤米松

Abstract: Objective: To evaluate the efficacy of halometasone in the treatment of erythema induced by Pulsed Dye Laser (PDL) irradiation for port wine stain (PWS). Methods: A total of 40 patients with PWS were enrolled in this study and randomly assigned into two regimens: PDL+Vaseline and PDL+halometasone. All patients were given a single treatment of PDL with a 595nm wavelength, 8.0-13.5 J/cm2, 1.5 milliseconds pulse duration and 7mm spot size. The patients in the PDL+halometasone group received topical halometasone for 1 day.and were followed-up at day 3, 7 and one month. Results: The erythema scores were 0.4±0.82 and 0.9±0.91 in the treatment group and control group respectively. The scab scores were 1.15±0.77 and 1.65±1.22 in the treatment group and control group respectively. The differences between the two groups were statistically significant (P<0.05). The duration of erythema lasted for 3.7±8.11/days and 7.3±10.49/days in the treatment group and control group, with a significant difference in the two groups (P<0.05). Conclusion: Topical halometasone can significantly reduce acute inflammatory reactions induced by PDL for the treatment of PWS.

Key words: Port Wine Stain, Pulsed Dye Laser, halometasone, adverse effects