中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (5): 313-316.

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妊娠泛发性脓疱型银屑病研究进展

李温如1 马丽俐2方一妙3 王 佳1 李芳芳1   

  1. 1 浙江中医药大学，杭州310006 2 浙江中医药大学附属第一医院，杭州310006
  • 出版日期:2016-05-15 发布日期:2018-12-25
  • 通讯作者: 马丽俐，E-mail:ma_lili@hotmail.com

Update of generalized pustular psoriasis of pregnancy

LI Wenru1, MA Lili2, FANG Yimiao1, WANG Jia1, LI Fangfang1.   

  1. 1. Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Chnia; 2. Zhejiang Provincial Hospital of TCM, Hangzhou 310006,Chnia
  • Online:2016-05-15 Published:2018-12-25
  • Contact: MA Lili, E-mail: ma_lili@hotmail.com

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摘要： 妊娠泛发性脓疱型银屑病（GPPP）是妊娠期发生的一种罕见而严重的脓疱型银屑病。临床以全身急性泛发性红斑,伴浅在性无菌性脓疱为特征，发展迅速，可融合成脓湖，常伴高热、寒战等严重全身症状，甚至危及母胎生命。糖皮质激素、环孢素、TNF-α抑制剂等治疗有一定疗效，可降低GPPP死亡率。本文从病因、治疗等方面对GPPP研究进展进行概述。

关键词: 妊娠, 泛发性脓疱型银屑病

Abstract: Generalized pustular psoriasis of pregnancy (GPPP) is a type of rare and severe pustular psoriasis. It is clinically characterized by acute eruption of generalized erythema with superficial sterile pustules, which may rapidly coalesce to form lakes of pus. The patient always accompanied by severe systemic symptoms，such as fever and chills, which can even be life-threatening to mater and fetus. The treatment of GPPP is still challenging, although the mortality has been decreased with the therapy of steroids，cyclosporin，TNF-α antagonists. This article aims to review the update of the etiology, treatment and other aspects of GPPP.

Key words: pregnancy, generalized pustular psoriasis