RPR titers,neurosyphilis ,"/> 血清RPR滴度与神经梅毒相关性分析

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (10): 577-579,591.

• 论著 •    下一篇

血清RPR滴度与神经梅毒相关性分析

卢改会1，2  普雄明2   

  1. 1新疆医科大学，乌鲁木齐，830031
    2新疆维吾尔自治区人民医院，乌鲁木齐，830031
  • 出版日期:2017-10-15 发布日期:2018-12-06
  • 通讯作者: 普雄明，E-mail：puxiongming@126.com

Correlation between neurosyphilis and serum RPR titers

LU Gaihui1，2, PU Xiongming2.   

  1. 1. Xinjiang Medical University, Urumqi 830031, China; 2. The Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830001, China
  • Online:2017-10-15 Published:2018-12-06
  • Contact: PU Xiongming, E-mail: puxiongming@126.com

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摘要： 目的：确定梅毒患者血清RPR滴度神经梅毒的相关性。方法：2013年6月至2016年6月就诊的360例梅毒患者(合并HIV感染120例)行腰椎穿刺及神经梅毒相关检查。结果：240例非HIV感染患者中，神经梅毒确诊或疑似病例68例，阳性率28.33%。120例HIV感染患者中，神经梅毒确诊或疑似病例61例，阳性率50.83%。HIV感染组中血RPR滴度对数为1∶1,1∶2,1∶4,1∶8,1∶16,1∶32的患者中神经梅毒阳性率分别为0%，33.33%，40%，75%，75%，66.67%，非HIV感染组分别为10%，15.38%，32.14%，35.71%，50%，50%，两组中神经梅毒阳性率与血清滴度均呈线性相关（P<0.05）。结论：神经梅毒与血清RPR滴度相关，滴度越高，神经梅毒可能性越大。

关键词: RPR滴度, 神经梅毒

Abstract: Objective: To determine the correlation between the serum RPR titers and neurosyphilis. Methods: Three hundred and sixty patients with syphilis (120 with HIV) diagnosed from June 2013 to June 2016 were treated with lumbar puncture, CSF test and serum RPR titers test. Results: Sixty eight (28.33%) and 61(50.83%) patients were confirmed or suspected as having neurosyphilis in 240 patients with non-HIV infection and 180 patients with HIV infection respectively. The neurosyphilis positivity rates of the RPR titers 1∶1, 1∶2, 1∶4, 1∶8, 1∶16, 1∶32 in the patients with HIV-infection were 0%, 33.33%, 40%, 75%, 75% and 66.67% respectively, while in the patients with non-HIV infection the neurosyphilis positivity rates were 10%，15.38%，32.14%，35.71%，50% and 50% respectively. The syphilis positivity rate was linearly correlated with the serum RPR level in the patients (P<0.05). Conclusion: The neurosyphilis positivity rate was correlated with the serum RPR titer and the higher the serum titers level is, the higher the risk of neurosyphilis will be.

Key words:

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RPR titers, neurosyphilis