中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (5): 275-277.doi: 10.12144/zgmfskin202005275

• 论著 • 上一篇    下一篇

36例神经梅毒临床资料分析

王海彦,陈宏泉,陆晓鸥,曹馨元,鄢洁   

  1. 青岛大学附属医院皮肤科，山东青岛，266003
  • 出版日期:2020-05-15 发布日期:2020-05-28
  • 通讯作者: 陈宏泉，E-mail：chhq6198@163.com

Analysis of clinical data of 36 cases with neurosyphilis

WANG Haiyan, CHEN Hongquan, LU Xiaoou, CAO Xinyuan, YAN Jie   

  1. Department of Dermatology, Affiliated Hospital of Qingdao University, Qingdao 266003, China
  • Online:2020-05-15 Published:2020-05-28
  • Contact: CHEN Hongquan, E-mail: chhq6198@163.com

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摘要： 对我院2010-2019年收治的36例HIV阴性的神经梅毒患者资料进行回顾性分析。36例患者中男29例，女7例；平均年龄49岁；无症状神经梅毒9例，平均年龄(36.07±8.05)岁，症状性神经梅毒27例，平均年龄(58.12±13.33)岁，差异具有统计学意义（P＜0.001）；脑脊液检查示：TPPA阳性36例， RPR阳性21例；白细胞升高13例；蛋白阳性24例。症状性神经梅毒组脑脊液白细胞计数、蛋白质阳性率、RPR阳性率和蛋白质定量水平高于无症状神经梅毒组，差异均有统计学意义（P=0.005；P=0.036；P=0.019；P=0.002）。

关键词: 神经梅毒, 临床特点, 脑脊液

Abstract: The data of 36 patients with neurosyphilis in our hospital from 2010 to 2019 was analyzed retrospectively. The average age of 36 patients, including 29 males and 7 females, was 49 years old. Of 36 patients, 27 were symptomatic neurosyphilis and 9 were asymptomatic neurosyphilis. The average age in the symptomatic neurosyphilis group was 58.12±13.33, which was older than that in the asymptomatic neurosyphilis group (36.07±8.05), with a significant difference (P＜0.001). The tests of CSF showed that TPPA was positive in 36 cases and RPR in 21 cases. The increase of the number of leukocytes in CSF in 13 cases, the increase of protein in 24 cases. The laboratory findings showed WBC counts, protein positivity rate, RPR positivity rate, protein quantification of CSF in the symptomatic neurosyphilis group were higher than those in the asymptomatic neurosyphilis group (P=0.005；P=0.036；P=0.002；P=0.019). 

Key words: neurosyphilis, clinical features, cerebrospinal fluid