中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (11): 653-656.

• 论著 • 上一篇    下一篇

反射式共聚焦激光扫描显微镜检测毛囊蠕形螨感染的临床应用

陈蕾  高峰  于维恒  孙文启  丁惠玲   

  1. 潍坊市皮肤病防治所，山东潍坊，261061
  • 出版日期:2017-11-15 发布日期:2018-12-11
  • 通讯作者: 陈蕾，E-mail：cl_cp@126.com

Clinical application of reflectance confocal microscopy for monitoring the density of demodex mites

CHEN Lei, GAO Feng, YU Weiheng, SUN Wenqi, DING Huiling.   

  1. Weifang Institude of Dermatology, Shandong Weifang 261061, China
  • Online:2017-11-15 Published:2018-12-11
  • Contact: CHEN Lei, E-mail: cl_cp@126.com

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摘要： 目的：探讨反射式共聚焦激光扫描显微镜（RCM）在毛囊蠕形螨检测中的临床应用。方法：对临床52例酒渣鼻患者采用挤压法、标准化皮肤表层取材法（SSSB）及RCM进行毛囊蠕形螨检测，并对其阳性率、高螨密度检出率（蠕形螨≥5个/cm2）及单位面积内毛囊蠕形螨平均密度进行对比分析。结果：挤压法、标准化皮肤表层取材法（SSSB）及RCM法的阳性率分别为69.23%、78.85%、100%。单位面积内毛囊蠕形螨平均密度分别为8.21±6.45、16.22±13.12、410.8±203.2。结论：RCM法在毛囊蠕形螨检测中是一种更为敏感、准确、简便的方法。

关键词: 反射式共聚焦激光扫描显微镜, 标准化皮肤表层取材法, 挤压法, 毛囊蠕形螨

Abstract: Objective: To determine the role of reflectance confocal microscopy (RCM) for monitoring the density of demodex mites. Methods: The positivity rate, high number of mites (≥5 mites /cm2) and mean number of mites per 10 mm2 of demodex mites in 52 patients with rosacea were detected by extrusion method, standardized skin surface biopsy (SSSB) and RCM respectively. Results: The positivity rates of extrusion method, SSSB and RCM were 69.23%, 78.85% and 100%  and the mean number of mites per 10 mm2 was 8.21±6.45, 16.22±13.12 and 410.8±203.2. Conclusion: RCM is more sensitive and simple for the detection of demodex mites in the patients with rosacea. 

Key words: reflectance confocal microscopy, standardized skin surface biopsy, extrusion method, demodex mites