atopic dermatitis,vitamin D,severity ,"/> 儿童特应性皮炎严重程度与血清维生素D水平相关性研究

中国麻风皮肤病杂志 ›› 2017, Vol. 33 ›› Issue (7): 390-393.

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儿童特应性皮炎严重程度与血清维生素D水平相关性研究

苏  伟 高  莹 张高磊 张  升 刘  燕 吴建新 刘晓雁   

  1. 首都儿科研究所附属儿童医院，北京，100020
  • 出版日期:2017-07-15 发布日期:2018-12-01
  • 通讯作者: 苏伟，E-mail:drsuwei@sina.com

Association between serum vitamin D levels and the severity of atopic dermatitis in children

SU Wei, GAO Ying, ZHANG Gaolei, ZHANG Sheng, WU Jianxin, LIU Xiaoyan.#br#   

  1. Capital Institute of Pediatrics, Beijing 100020, China

  • Online:2017-07-15 Published:2018-12-01
  • Contact: SU Wei, E-mail:drsuwei@sina.com

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摘要： 目的：明确儿童特应性皮炎（AD）严重程度与血清维生素D（VitD）水平之间的相关性。方法：检测100例AD患儿血清中VitD水平。按照血清VitD的水平，分为正常（>75nmol/L），不足（50～75nmol/L）和缺乏（<50nmol/L）。根据SCORAD评分，确定患儿AD疾病的严重程度，其中<25分为轻度，25～50分为中度AD，>50分为重度AD。利用多元线性回归分析，检验VitD水平及疾病严重程度的相关性。结果：100例患儿中，轻度AD患儿5例，其中VitD水平正常1例,不足3例,缺乏2例；中度AD患儿36例，其中VitD水平正常9例,不足11例,缺乏16例，重度AD患儿58例,其中VitD水平正常8例,不足16例,缺乏34例。多因素分析结果显示VitD水平与AD严重程度之间具有负向关联。结论：VitD的水平可能与特异性皮炎的严重程度有关。

关键词: 特应性皮炎, 维生素D, 严重程度

Abstract: Objective: To determine the correlation between serum vitamin D levels and severity of atopic dermatitis （AD）in children. Methods: The serum level of 25-hydroxyvitamin D （25-OHD）in 100 children with AD was detected. Serum vitamin D levels were classified as sufficient (>75nmol/L), insufficient (50-75nmol/L) and deficient (<50nmol/L). The severity of AD were classified as mild (0-25), moderate (25-50) and severe (>50) by Scoring Atopotic Dermatitis Index. The relationship between the serum vitamin D levels and the severity of atopotic dermatitis was detected by multiple linear regressions. Results: Five patients were classified as mild AD, of them, 25-hydroxyvitamin D was sufficient in one patient, insufficient in 3 and deficient in 2. Thirty six patients were classified as moderate AD, of them, 25-hydroxyvitamin D was sufficient in 9 patients, insufficient in 11 and deficient in 16. Fifty eight patients were classified as severe AD, of them, 25-hydroxyvitamin D was sufficient in 8 patients, insufficient in 16 and deficient in 34. The multivariate analysis showed that the vitamin D deficiency was related with the severity of AD. Conclusion: The level of serum 25-hydroxyvitamin D was associated with the severity of AD.

Key words: atopic dermatitis')">

atopic dermatitis, vitamin D, severity