中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (11): 694-697.

• 综述 • 上一篇    下一篇

单纯疱疹病毒感染的复发机制与治疗的研究进展

杨荷丹，蒋娟   

  1. 中国医学科学院北京协和医学院皮肤病医院，南京，210042
  • 出版日期:2018-11-15 发布日期:2018-12-02
  • 通讯作者: 蒋娟，E-mail: drjjiang@vip.163.com

Update of mechanism and treatment of herpes simplex virus infection

YANG Hedan, JIANG Juan   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2018-11-15 Published:2018-12-02
  • Contact: JIANG Juan, E-mail: drjjiang@vip.163.com

PDF (PC)

176

摘要： 单纯疱疹病毒可潜伏于宿主感觉神经节并周期性地再激活引起感染复发，其部分基因产物可帮助维持潜伏状态，并可抑制感染细胞自噬及宿主的抗病毒作用以逃避宿主的免疫监视。耐药病毒株的出现使传统抗病毒药物的作用受限，近年来研究发现新型抗病毒药物如Pritelivir和Amenamevir可显著抑制病毒复制，减少病毒脱落，本文对单纯疱疹病毒的复发机制及治疗进展进行了综述。

关键词: 单纯疱疹病毒, 复发机制, 抗病毒治疗

Abstract: Herpes simplex virus (HSV) causes infection recurrence by lurking in the host sensory ganglia and periodically reactivating. Some gene products of HSV are helpful to maintain its latent state and evade host immune surveillance by inhibiting the autophagy of infected cells and the antiviral effects of the hosts. The effect of traditional antiviral drugs has been limited due to drug-resistance. New antiviral drugs, such as Pritelivir and Amenamevir can significantly inhibit virus replication and reduce virus shedding. The update of the mechanism and treatment of herpes simplex virus infection is reviewed in this paper.

Key words: herpes simplex virus, recurrent mechanism, antiviral therapy