Abstract: The clinical features of 17 patients with acquired reactive perforating collagenosis (ARPC) in our department ?were?analyzed?retrospectively. There were 8 males and 9 females .The average age was 51.06±16.82, ranging from 19 to 81 years old. The courses of the patients were from one week to 5 years and the average course was 9.54±0.56 months. Eight patients complicated with diabetes, 7 with hypertension, 5 with chronic renal failure. The lesions mainly distributed symmetrically on trunk (82.35%) and lower extremities (76.47%) with sever pruritus and Koebner phenomenon. Typical lesions presented with papules in yellow bean size and yellow keratotic plugs in the center which were hard to remove. Pathological examination showed curly and broken collagen bundles eliminated vertically through a cup-shaped crater in epidermis. The treatment was mainly to control pruritus and systemic diseases.The symptoms of pruritus were improved in 8 patients, while the condition of 4 patients had no obvious change and 4 patients had new rash.. One patient died from heart?failure after one week of diagnosis.