中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (9): 552-554.

• 经典病例研究 • 上一篇    下一篇

栅栏状中性粒细胞肉芽肿性皮炎合并强直性脊柱炎一例

甘璐，陈浩，孙建方   

  1. 中国医学科学院北京协和医学院皮肤病研究所病理科，南京，210042
  • 出版日期:2018-09-15 发布日期:2018-12-11
  • 通讯作者: 孙建方，E-mail：fangmin5758@aliyun.com

Palisade neutrophilic and granulomatous dermatitis complicated with ankylosing spondylitis: a case report

GAN Lu, CHEN Hao, SUN Jian-fang   

  1. Department of Pathology, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042 , China
  • Online:2018-09-15 Published:2018-12-11
  • Contact: SUN Jian-fang, E-mail:fangmin5758@aliyun.com

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摘要： 患者，男，55岁。四肢暗红色斑块、脱屑5年。既往有强直性脊柱炎病史。皮损组织病理学检查示真皮内上皮细胞肉芽肿改变，部分区域上皮细胞呈栅栏状排列，局部伴有中性粒细胞、淋巴细胞浸润。实验室检查抗核抗体、SSA、SSB、抗双链DNA等为阴性，HLA-B27为阳性。诊断：栅栏状中性粒细胞肉芽肿性皮炎合并强直性脊柱炎。

关键词: 栅栏状中性粒细胞肉芽肿性皮炎, 强直性脊柱炎

Abstract: A 55-year-old male presented with erythematous plaques and scales on the extensor surface of extremities for 5 years. He has a history of ankylosing spondylitis (AS) for 10 years.. The biopsy showed granulomatous?nodules in the dermis, and some histiocytes, lymphocytes, neutrophils in a pattern of palisading arrangement. Antinuclear antibody, anti-SS-B, anti-SS-A and anti–double-stranded DNA were negative. HLA-B27 was positive. The diagnosis of palisaded neutrophilic granulomatous dermatitis companied with ankylosing spondylitis was made.

Key words: palisaded neutrophilic granulomatous dermatitis, ankylosing spondylitis