中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (11): 799-801.doi: 10.12144/zgmfskin202411799

• 临床研究 • 上一篇    下一篇

传染性软疣样先天自愈性朗格汉斯细胞组织细胞增生症一例并文献复习

陈学超1,2,王建文1,2,卢宪梅1,2,杨青1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-11-15 发布日期:2024-10-14

Infectious soft wart like congenital self-healing Langerhans cell histiocytosis: a case report and literature review

CHEN Xuechao1,2, WANG Jianwen1,2, LU Xianmei1,2, YANG Qing1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-11-15 Published:2024-10-14

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摘要： 先天自愈性朗格汉斯细胞组织细胞增生症是一种少见的新生儿疾病，初发年龄多为出生至9个月，皮损表现多样，多为丘疹、结节、丘疱疹，皮下结节等。本文报道一例3个月女性患儿，躯干、下肢散发粟粒大小丘疹，部分皮疹中央可见脐凹，部分皮疹顶部结痂。皮损组织病理及免疫组化染色符合朗格汉斯细胞组织细胞增生症。未予治疗，随访4 个月皮疹消退，随访1年无新发皮疹。

关键词: 朗格汉斯组织细胞增生症, 自愈性, 先天性

Abstract: Congenital self-healing Langerhans cell histiocytosis is a rare disease in newborn. The onset age of the disease was mostly between birth and 9 months. The skin lesions were mostly papules, nodules, papuloherpes, subcutaneous nodules, etc. We report a three-month-old girl presented with sporadic miliary papules on the trunk and lower limbs, with the umbilical-fovea in the center or crusts on the top of papules. The features of pathological examination and immunohistochemical staining of the skin lesions were consistent with Langerhans cell histiocytosis. The patient received no treatment, the rash subsided after 4 months follow-up, and no new rash occurred after 1 year follow-up.

Key words: Langerhans cell histiocytosis, self-healing, congenital