中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (1): 37-42.doi: 10.12144/zgmfskin202501037

• 临床研究 • 上一篇    下一篇

佩索利单抗治疗急性泛发性脓疱型银屑病二例并文献复习

张猛，孙悦鑫，李志瑜，包军，周映   

  1. 南京大学医学院附属鼓楼医院皮肤科，江苏南京，210008
  • 出版日期:2025-01-15 发布日期:2024-12-23

Acute generalized pustular psoriasis treated with spesolimab: two cases report and literature review

ZHANG Meng, SUN Yuexin, LI Zhiyu, BAO Jun, ZHOU Ying   

  1. Department of Dermatology, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China
  • Online:2025-01-15 Published:2024-12-23

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摘要： 报道佩索利单抗治疗2例急性泛发性脓疱型银屑病（GPP）的疗效。2例患者均为男性，均有寻常型银屑病病史，均治疗1次 (900 mg)。治疗前24 h的GPP医师总体评估（GPPGA）脓疱评分均为4，GPP皮损面积和严重程度指数（GPPASI）评分分别为48.0和59.3。2例患者治疗后48 h GPPGA脓疱单项评分均0，GPPASI评分改善率为91.04%和89.21%。治疗过程中, 2例患者的实验室指标如白细胞计数、中性粒细胞计数及比例、C反应蛋白均在应用佩索利单抗后48 h内逐步回归或接近正常水平，且观察1周无反复，体温在给药后24 h内恢复正常且无反复。

关键词: 急性泛发性脓疱型银屑病, 佩索利单抗

Abstract: We report two patients with acute generalized pustular psoriasis (GPP) treated with spesolimab of a single 900 mg intravenous dose. Both patients were male and had a history of psoriasis vulgaris. The pretreatment generalized pustular psoriasis physician's general assessment (GPPGA) score was 4 in both patients. The scores of generalized pustular psoriasis area and severity index (GPPASI) were 48.0 and 59.3, respectively. The GPPGA pustular score of both were 0 at 48 hours after treatment, and the improvement rates of GPPASI were 91.04% and 89.21%, respectively. Laboratory parameters including white blood cell count, neutrophil count, neutrophil ratio, and C-reactive protein returned to or near normal levels within 48 hours after the application of spesolimab, and there was no recurrence during the 1-week observation. Body temperature returned to normal within 24 hours after the administration of spesolimab without recurrence.

Key words: acute generalized pustular psoriasis, spesolimab