中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (2): 127-129.doi: 10.12144/zgmfskin202502127

• 病例报告 • 上一篇    下一篇

佩索利单抗治疗泛发性脓疱型银屑病二例

宋平平1,2,王娜1,2*,杜东红1,2,刘静1,2,冉德琳1,2,杨宝琦1,2   

  1. 1山东第一医科大学附属皮肤病医院,山东济南,250022; 2山东省皮肤病性病防治研究所,山东济南,250022 *共同第一作者
  • 出版日期:2025-02-15 发布日期:2025-01-22

Generalized pustular psoriasis successfully treated with spesolimab: two cases report

SONG Pingping1,2*, WANG Na1,2*, DU Donghong1,2*, LIU Jing1,2, RAN Delin1,2, YANG Baoqi1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China *Co-first author
  • Online:2025-02-15 Published:2025-01-22

摘要: 本文报道2例佩索利单抗治疗泛发性脓疱型银屑病患者。2例患者常规治疗效果不佳,排除感染性疾病后,均给予佩索利单抗900 mg 1次治疗。患者1治疗后第2天体温正常,第5天所有脓疱消退,未见新发脓疱;患者2脓疱逐渐消退,第5天未见新发脓疱,第9天体温正常。2例患者治疗期间均未出现明显不良反应。

关键词: 泛发性脓疱型银屑病, 佩索利单抗, 治疗

Abstract: We report 2 cases of generalized pustular psoriasis(GPP) patients treated with spesolimab. Both patients had poor responses to conventional treatments, and were given a single dose of 900 mg of spesolimab after excluding infectious diseases. The temperature returned to normal on the second day after treatment, and all pustules subsided on the fifth day in one patient. The pustules gradually subsided on the fifth day and the temperature returned to normal on the ninth day in another patient. Neither patient experienced significant adverse reactions during the treatment period.

Key words: generalized pustular psoriasis, spesolimab, therapy