中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (4): 262-266.doi: 10.12144/zgmfskin202504262

• 论著 • 上一篇    下一篇

12例重症麻风反应患者临床分析

黄天福,王国春,李兴敏,杨莉水,周继巧,龙恒,宗祥广   

  1. 文山州皮肤病防治所（文山州皮肤病专科医院）,云南文山，663099
  • 出版日期:2025-04-15 发布日期:2025-04-08

Clinical analysis of 12 patients with severe leprosy reaction

HUANG Tianfu, WANG Guochun, LI Xingmin, YANG Lishui, ZHOU Jiqiao, LONG Heng, ZONG Xiangguang   

  1. Wenshan Prefecture Dermatology Prevention and Treatment Institute (Wenshan Prefecture Dermatology Specialist Hospital), Wenshan 663099, China
  • Online:2025-04-15 Published:2025-04-08

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摘要： 目的：总结重症麻风反应患者的临床特征、治疗及转归。方法：采用描述性统计学方法对我院2022年1月至2023年12月收治的12例重症麻风反应患者的临床资料进行回顾性分析。结果：12例患者，男8例，女4例，平均年龄36.08岁，均为中间界线类偏瘤型麻风，其中Ⅰ型麻风反应2例，Ⅱ型麻风反应6例，混合型麻风反应4例。11例伴有神经炎表现（91.67%），发生2级畸残4例，1级畸残3例，畸残比为58.33%。所有患者均给予糖皮质激素治疗，部分联合沙利度胺或其他免疫抑制剂，12例患者麻风反应均消退，4例患者（33.33%）出院后麻风反应加重或再发。结论：重症麻风反应病情复杂易复发，神经受累常见，糖皮质激素是主要治疗药物。

关键词: 麻风, 麻风反应, 回顾分析

Abstract: Objective: To summarize the clinical features, treatment and outcome of patients with severe leprosy reaction retrospectively. Methods: Descriptive statistics were used to analyze the clinical data of 12 patients with severe leprosy reaction admitted to our hospital from January 2022 to December 2023 retrospectively. Results: Among the 12 patients, there were 8 males and 4 females with an average age of 36.08 years. All cases were borderline lepromatous, including 2 cases of type I leprosy, 6 cases of type II leprosy and 4 cases of mixed leprosy. 11 cases were accompanied by neuritis (91.67%), 4 cases had grade 2 deformity, 3 cases had grade 1 deformity, and the deformity ratio was 58.33%. All patients were treated with glucocorticoid, some with thalidomide or other immunosuppressants, and the leprosy response subsided in all 12 patients. The leprosy reaction worsened or recurred in 4 patients (33.33%) after discharge. Conclusion: The symptoms of severe leprosy reactions present complex and are prone to recurrence, nerve involvement is common, glucocorticoid is the main treatment.

Key words: leprosy, leprosy reaction, retrospective analysis