中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (7): 517-519.doi: 10.12144/zgmfskin202507517

• 病例报告 • 上一篇    下一篇

多发巨大尿毒症性肿瘤样钙质沉着症一例

王亚男*,王艺璇*,晋红中   

  1. 中国医学科学院北京协和医学院北京协和医院皮肤科，疑难重症及罕见病国家重点实验室，国家皮肤与免疫疾病临床医学研究中心，北京，100730 *共同第一作者
  • 出版日期:2025-07-15 发布日期:2025-07-07

Multiple giant uremic tumoral calcinosis: a case report

WANG Yanan*, WANG Yixuan*, JIN Hongzhong   

  1. Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China *Co-first author
  • Online:2025-07-15 Published:2025-07-07

PDF (PC)

27

摘要： 尿毒症性肿瘤样钙质沉着症是一种罕见的软组织钙化疾病，常发生于大关节周围软组织中，本文报道一例。患者，男，25岁。肩背、肘关节巨大无痛性肿物2年。慢性肾衰史10年。实验室检查示血肌酐1098 μmol/L，血磷3.38 mmol/L、钙磷乘积6.83 mmol2/L2。MRI示右肘部肌间隙内多发巨大团块样混杂信号影，多发囊状长 T1 长 T2 信号。患者肿物行右肘关节肿物切除术，HE染色示致密的透明化间质，内有多个囊腔，囊腔内含大量坏死和钙化碎片，符合肿瘤样钙质沉着症。嘱患者限磷饮食和钙磷结合剂治疗。术后3个月，右肘部病灶原位复发，但生长速度较之前减慢。

关键词: 肿瘤样钙质沉着症, 钙质沉着症, 尿毒症

Abstract: Uremic tumoral calcinosis is a rare soft tissue calcification disease， that often occurs in the soft tissues around large joints. This paper reports a case of this disease. A 25-year-old man presented with multiple enlarging, painless masses on the bilateral scapula, elbow joints, and shoulder joints for 2 years. He had a history of end-stage renal disease for 10 years. Laboratory tests revealed the elevated level of serum creatinine(1098 μmol/L), serum phosphate(3.38 mmol/L) and calcium-phosphorus product (6.83 mmol2/L2). MRI of the right elbow mass revealed calcinosis with heterogeneous signal intensity. The patient subsequently underwent surgical resection of the mass. The biopsy features of dense hyaline stroma with multiple cysts containing necrotic and calcified debris were accordance with tumoral calcinosis. The patient was treated with dietary phosphate restriction and phosphate binders. Three months after the resection, the lesion recurred at the original site but the growth rate was slower than before.

Key words: uremic tumoral calcinosis, calcinosis, uremia