中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (7): 514-516.doi: 10.12144/zgmfskin202507514

• 病例报告 • 上一篇    下一篇

皮肤血管内NK/T细胞淋巴瘤一例

黄鹤1,胡中柱1,刘美娜1,胡彬2   

  1. 1黄冈市中心医院皮肤科，湖北黄冈，438000；2武汉市第一医院皮肤科，湖北武汉，430022
  • 出版日期:2025-07-15 发布日期:2025-07-07

Cutaneous intravascular NK/T cell lymphoma: a case report

HUANG He1, HU Zhongzhu1, LIU Meina1, HU Bin2   

  1. 1 Department of Dermatology, Huanggang Central Hospital, Huanggang 438000, China; 2 Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, China
  • Online:2025-07-15 Published:2025-07-07

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摘要： T细胞和NK细胞来源的血管内淋巴瘤极为罕见,本文报道一例。患者,男，76岁。间断发热1个月余，双大腿红斑半个月。皮损组织病理示真皮及脂肪见小血管内数量不等的大的异型的单一核细胞。免疫组化：EBER原位杂交阳性。CD3(+), CD4(+), CD8(+), CD56(+), TIA-1(+), Gr-B(+), Perforin(+), Ki-67(60%+)。诊断为血管内NK/T细胞淋巴瘤。P-Gemox化疗方案治疗4个疗程后予以西达本胺+信迪利单抗治疗，红斑基本消退，随访6个月肿瘤无进展。

关键词: 血管内NK-T细胞淋巴瘤, 皮肤表现, 免疫组织化学

Abstract: Intravascular lymphoma of T and NK cell origin is extremely rare, herein, we report a case. A 76-year-old male presented with intermittent fever for more than one month, and erythema on both thighs for half a month. Pathological examination of skin lesions showed large and atypical mononuclear cells of varying numbers were found in small blood vessels in the dermis and fat. Immunohistochemistry showed positive EBER in situ hybridization, CD3(+), CD4(+), CD8(+), CD56(+), TIA-1(+), Gr-B(+), Perforin(+), Ki-67(60%+). The diagnosis of intravascular NK/T cell lymphoma was made. After 4 courses of P-Gemox treatment, the patient was given chidamide and sintilimab. The rash on both thighs almost disappeared, and there was no tumor progression during the 6-month follow-up.

Key words: intravascular NK/T cell lymphoma, skin manifestations, immunohistochemistry