中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (10): 731-734.doi: 10.12144/zgmfskin202610731

• 病例报告 • 上一篇    下一篇

唐氏综合征合并特应性皮炎及黑棘皮病一例

成安琪1,2,李健炜1,2,王禹凝1,2,郑荣涛1,2,李珍1,2,刘红1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2026-10-15 发布日期:2026-10-09

Down syndrome with atopic dermatitis and acanthosis nigricans: a case report

CHENG Anqi1,2, LI Jianwei1,2, WANG Yuning1,2, ZHENG Rongtao1,2, LI Zhen1,2, LIU Hong1,2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China: 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2026-10-15 Published:2026-10-09

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摘要： 唐氏综合征（21三体综合征）是一种累及多系统的染色体异常疾病，其皮肤表现复杂多样。本文报道1例唐氏综合征合并特应性皮炎及黑棘皮病患者。给予口服枸橼酸托法替布联合外用治疗后，瘙痒及皮损明显改善。通过本病例报道并结合文献复习，旨在提高对唐氏综合征相关皮肤疾病，尤其是免疫及代谢异常相关皮肤表现的认识，为临床诊治提供参考。

关键词: 唐氏综合征, 21三体综合征, 黑棘皮病, 特应性皮炎

Abstract: Down syndrome (trisomy 21) is a chromosomal disorder involving multiple organ systems, with diverse cutaneous manifestations. We report a case of Down syndrome complicated by atopic dermatitis and acanthosis nigricans. The patient was treated with oral tofacitinib combined with topical therapy, with improvement in pruritus and skin lesions. By reporting this case and reviewing literatures, we intend to improve recognition of cutaneous disorders associated with Down syndrome, especially those related to immune and metabolic abnormalities, and to provide a reference for clinical practice.

Key words: Down syndrome, trisomy 21 syndrome, acanthosis nigricans, atopic dermatitis