中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (11): 815-816.doi: 10.12144/zgmfskin202611815

• 病例报告 • 上一篇    下一篇

马拉色菌相关儿童脂溢性角化病一例

龚诗蕊,纪秋琴,许晓羽,路遥   

  1. 电子科技大学医学院附属妇女儿童医院/成都市妇女儿童中心医院，四川成都，611731
  • 出版日期:2026-11-15 发布日期:2026-10-29

Malassezia associated seborrheic keratosis in child: a case report

GONG Shirui, JI Qiuqin, XU Xiaoyu, LU Yao   

  1. Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 611731, China
  • Online:2026-11-15 Published:2026-10-29

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摘要： 脂溢性角化病（seborrheic keratosis，SK）是一种常见的良性表皮肿瘤，多见于中老年人，在儿童中极为罕见，其发病机制尚未完全明确。近年来，研究报道微生物，尤其是马拉色菌属的定植，可能参与SK的发生。本文报道一例伴有马拉色菌定植的儿童SK病例。患儿，女，11岁，腰部可见两个黑色疣状斑块，4年内逐渐增大。皮肤镜表现为脑回样结构伴粉刺样开口。组织病理示角化过度及假性角囊肿，PAS染色示角质层内大量马拉色菌。

关键词: 脂溢性角化病, 马拉色菌, 儿童皮肤病学, 角化异常性疾病, 角化过度

Abstract: Seborrheic keratosis (SK) is a common benign epidermal tumor that predominantly affects adults and is exceptionally rare in children with its pathogenesis not yet fully elucidated. Recent studies have reported that colonization by microorganisms, particularly Malassezia spp, may be implicated in the development of SK. Herein, we report a case of SK in a child complicated with Malassezia colonization. The patient was an 11-year-old girl presenting with two black verrucous plaques on the lumbar region that had gradually enlarged over four years. Dermoscopy revealed cerebriform structures with comedo-like openings. Histopathological examination demonstrated hyperkeratosis and pseudohorn cysts, and PAS staining detected abundant Malassezia within the stratum corneum.

Key words: seborrheic keratosis, Malassezia, pediatric dermatology, keratinization disorders, hyperkeratosis