中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (3): 190-193.doi: 10.12144/zgmfskin202603190

• 临床研究 • 上一篇    下一篇

乌帕替尼治疗家族性良性慢性天疱疮一例并文献复习

胡轶阳1,2,3,王玉琳1,2,3,胡洁1,2,3,赵琪1,2,3,王如意1,2,3,李乘宇3,蔡佳3,李香凝3,唐利利1,2,3,范星1,2,3   

  1. 1安徽医科大学第一附属医院皮肤性病科，安徽合肥，230022；2皮肤病学教育部重点实验室(安徽医科大学)，安徽合肥，230022；3安徽医科大学，安徽合肥，230032
  • 出版日期:2026-03-15 发布日期:2026-03-10

Upadacitinib in the treatment of Hailey-Hailey disease: a case report and literature review

HU Yiyang1,2,3, WANG Yulin1,2,3, HU Jie1,2,3, ZHAO Qi1,2,3, WANG Ruyi1,2,3, LI Chengyu3, CAI Jia3, LI Xiangning3, TANG Lili1,2,3, FAN Xing1,2,3   

  1. 1 Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; 2 Key Laboratory of Dermatology(Anhui Medical University), Ministry of Education, Hefei 230022, China; 3 Anhui Medical University, Hefei 230032, China
  • Online:2026-03-15 Published:2026-03-10

PDF (PC)

3

摘要： 患者，男，50岁。家族性良性慢性天疱疮患者，曾使用“甲泼尼龙片、复方甘草酸苷片”等治疗，效果欠佳。既往有文献报道乌帕替尼治疗家族性良性慢性天疱疮患者的案例，经本患者知情同意后给予乌帕替尼15 mg，每日1次，治疗2周后，皮损明显干燥消退。继续维持治疗1个月后，皮损持续改善，无新发皮损。治疗2个月后随访，皮损改善稳定，无不良反应。

关键词: 乌帕替尼, 家族性良性慢性天疱疮, JAK抑制剂

Abstract: The patient, a 50-year-old male with Hailey-Hailey disease, had previously been treated with medications such as methylprednisolone tablets and compound glycyrrhizin tablets, but the response was unsatisfactory. Previous literature has reported cases of upadacitinib being used to treat Hailey-Hailey disease. After obtaining informed consent from the patient, he was administered upadacitinib 15 mg once daily. Following two weeks of treatment, the skin lesions showed significant drying and regression. After one additional month of maintenance therapy, the skin lesions continued to improve with no new lesions emerging. At the two-month follow-up, the skin lesions remained stable without any adverse reactions.

Key words: upadacitinib, Hailey-Hailey disease, JAK inhibitor