中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (4): 227-229.doi: 10.12144/zgmfskin202604227

• 新发与再发感染性皮肤病 • 上一篇    下一篇

皮肤诺卡菌病一例

解瑞凤1,李婵2,李岩峰2,张本利2,宋亚丽3   

  1. 1山东第一医科大学附属省立医院，山东济南，250021； 2山东大学附属公共卫生临床中心，山东济南，250102； 3上海交通大学医学院附属新华医院，上海，200092
  • 出版日期:2026-04-15 发布日期:2026-04-07

Cutaneous nocardiosis: a case report

XIE Ruifeng1, LI Chan2, LI Yanfeng2, ZHANG Benli2, SONG Yali3   

  1. 1 Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; 2 Public Health Clinical Center Affiliated to Shandong University, Jinan 250102, China; 3 Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2026-04-15 Published:2026-04-07

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摘要： 患者，女，52岁，左侧足背、足踝红肿伴丘疹、结节半年，多种抗生素治疗效果不佳。患者从事大棚蔬菜种植工作，有反复足部外伤史。组织病理示化脓性肉芽肿性炎症，六胺银染色见菌团结构，宏基因组二代测序（mNGS）确诊为巴西诺卡菌感染。予复方磺胺甲噁唑0.96 g每日2次口服，1个月后皮损明显好转。复习文献报道的12 例巴西诺卡菌感染病例，其中7例有土壤/植物接触史，提示农业从业者可能为巴西诺卡菌感染高危群体。

关键词: 皮肤诺卡菌病, 巴西诺卡菌, 宏基因组二代测序

Abstract: A 52-year-old female patient presented with redness, swelling, papules and nodules on the left dorsum pedis and ankle for half a year, which responded poorly to multiple antibiotics. She was engaged in greenhouse vegetable cultivation with a history of repeated foot trauma. Histopathology showed pyogenic granulomatous inflammation. Bacterial colonies were observed by hexamine silver staining. Metagenomic next-generation sequencing (mNGS) confirmed the diagnosis of Nocardia brasiliensis infection. The patient was treated with compound sulfamethoxazole 0.96 g twice daily, and the skin lesions improved significantly after 1 month. A review of 12 reported cases of Nocardia brasiliensis infection in the literature revealed that 7 cases had a history of soil/plant contact, suggesting that agricultural workers may be a high-risk group for Nocardia brasiliensis infection.

Key words: cutaneous nocardiosis, Nocardia brasiliensis, metagenomic next-generation sequencing (mNGS)