中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (6): 450-452.doi: 10.12144/zgmfskin202606450

• 病例报告 • 上一篇    下一篇

度普利尤单抗相关眼表疾病合并HSV-1及金黄色葡萄球菌感染一例

武萌伟1,刘佩泽1,李浩源1,陈翰祥2,郅莉莉1   

  1. 1山东第一医科大学第一附属医院（山东省千佛山医院）呼吸与危重症医学科，山东省呼吸疾病研究所过敏性疾病科，山东济南，250014；2山东第一医科大学第一附属医院（山东省千佛山医院）临床检验医学科，山东省医学检验重点实验室，山东济南，250014
  • 出版日期:2026-06-15 发布日期:2026-06-04

Dupilumab-associated ocular surface disease complicated with HSV-1 and Staphylococcus aureus infection: a case report

WU Mengwei1, LIU Peize1, LI Haoyuan1, CHEN Hanxiang2, ZHI Lili1   

  1. 1 Department of Respiratory and Critical Care Medicine, Shandong Provincial Qianfoshan Hospital, the First Affiliated Hospital of Shandong First Medical University, Jinan 250014, China; 2 Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Laboratory Medicine, Jinan 250014, China
  • Online:2026-06-15 Published:2026-06-04

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摘要： 度普利尤单抗是治疗中重度特应性皮炎（AD）的重要生物制剂，其常见不良反应为度普利尤单抗相关眼表疾病(DAOSD)，多以非感染性炎症为主。本文报道一例7岁AD患儿，度普利尤单抗治疗3个月后出现睑缘红斑、肿胀合并HSV-1及金黄色葡萄球菌感染，经局部抗病毒、抗菌治疗及短期停药后皮损完全消退，恢复用药后无复发。本病例提示DAOSD相关眼表局部免疫与屏障失衡，提升病毒与细菌易感性，临床需加强感染监测与早期干预。

关键词: 度普利尤单抗相关眼表疾病, 特应性皮炎, HSV-1, 金黄色葡萄球菌

Abstract: Dupilumab is an important biologic agent for the treatment of moderate to severe atopic dermatitis (AD). Its common adverse reaction is dupilumab-associated ocular surface disease (DAOSD), which is predominantly non-infectious inflammation. Herein, we report a 7-year-old boy with AD who presented with erythema and swelling of the eyelid margin complicated with herpes simplex virus type 1 (HSV-1) and Staphylococcus aureus infection after 3 months of dupilumab therapy. After topical antiviral and antibacterial therapy as well as short-term drug discontinuation, the skin lesions completely resolved, with no recurrence after drug resumption. This case indicates that DAOSD-associated local immune and barrier dysregulation of the ocular surface increases susceptibility to viral and bacterial infections. Clinically, strengthened infection monitoring and early intervention are warranted.

Key words: DAOSD, atopic dermatitis, HSV-1, Staphylococcus aureus