中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (6): 452-455.doi: 10.12144/zgmfskin202606452

• 病例报告 • 上一篇    下一篇

蕈样肉芽肿误诊为特应性皮炎予度普利尤单抗治疗后加重一例

林阳,牛贵业,张书成,李竹清,司晓青   

  1. 山东第一医科大学第一附属医院皮肤科，山东济南，250013
  • 出版日期:2026-06-15 发布日期:2026-06-04

Mycosis fungoides misdiagnosed as atopic dermatitis and aggravated after dupilumab treatment: a case report

LIN Yang, NIU Guiye, ZHANG Shucheng, LI Zhuqing, SI Xiaoqing   

  1. Department of Dermatology, First Affiliated Hospital of Shandong First Medical University, Jinan 250013, China
  • Online:2026-06-15 Published:2026-06-04

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摘要： 蕈样肉芽肿（mycosis fungoides, MF）早期皮损常呈非特异性湿疹样改变，容易误诊。本文报道1例MF患者误诊为特应性皮炎(atopic dermatitis,AD)，应用度普利尤单抗治疗后病情加重的病例。停用生物制剂并给予NB-UVB治疗后，病情好转。本病例提示对于拟诊AD的老年患者，若出现提示MF可能性的临床警示特征，应常规行多点、重复取材并局部停药2周的皮肤组织病理检查，避免误诊导致病情进展。

关键词: 蕈样肉芽肿, 度普利尤单抗, 皮肤T细胞淋巴瘤, 淋巴样反应

Abstract: The early lesions of mycosis fungoides (MF) often present as non-specific eczematous changes, which are clinically difficult to distinguish from atopic dermatitis (AD). We report a case of MF patient who was misdiagnosed as atopic dermatitis in another hospital and experienced disease exacerbation after treatment with dupilumab. After discontinuing the biological agent and NB-UVB, the patient's condition improved. This case suggests that for elderly patients diagnosed as suspected AD, if there are clinical warning features indicating the possibility of MF, routine multi-point and repeated skin tissue pathological examinations with local drug withdrawal for 2 weeks should be performed, so as to avoid disease progression caused by misdiagnosis.

Key words: mycosis fungoides, dupilumab, cutaneous T-cell lymphoma, lymphoid reactions