中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (2): 101-105.doi: 10.12144/zgmfskin202602101

• 临床研究 • 上一篇    下一篇

度普利尤单抗治疗妊娠类天疱疮一例并文献复习

黄敬然1，2,王蕾1，2,方零露1，2,周英1，2   

  1. 1广东医科大学附属医院皮肤性病研究所，广东湛江,524000; 2广东医科大学附属医院皮肤病与性病科，广东湛江,524000
  • 出版日期:2026-02-15 发布日期:2026-01-28

Dupilumab in the treatment of pemphigoid gestationis: a case report and literature review

HUANG Jingran1,2, WANG Lei1,2, FANG Linglu1,2， ZHOU Ying1,2   

  1. 1 Institute of Dermatology and Venereology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China; 2 Department of Dermatology and Venereology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524000, China
  • Online:2026-02-15 Published:2026-01-28

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摘要： 本文报道一例糖皮质激素治疗无效的妊娠类天疱疮（pemphigoid gestationis,PG）患者，采用度普利尤单抗治疗后取得显著疗效。该患者在孕23周时全身出现红斑、水疱，组织病理示表皮下以嗜酸性粒细胞为主的炎细胞浸润，直接免疫荧光示补体C3呈线状沉积于基底膜带。诊断为妊娠类天疱疮。患者首次注射度普利尤单抗600 mg后3天皮损即控制，后续每2周300 mg维持治疗实现糖皮质激素快速减量，最终足月分娩健康男婴。结合文献中共8例PG病例分析，度普利尤单抗展现出起效迅速、辅助降低糖皮质激素用量及母婴安全性良好的优势，为难治性PG提供了新的安全有效的治疗策略。

关键词: 妊娠类天疱疮, 度普利尤单抗

Abstract: This report presents a case of pemphigoid gestationis (PG) refractory to corticosteroid therapy, which was successfully treated with dupilumab. At 23 weeks of gestation, the patient presented with widespread erythema and blisters. The diagnosis of PG was confirmed by histopathology showing subepidermal blister with a predominant eosinophilic infiltrate and direct immunofluorescence demonstrating linear deposition of complement C3 along the basement membrane zone. The skin lesions were controlled within 3 days after the initial 600 mg dose of dupilumab. Subsequent maintenance therapy with 300 mg every 2 weeks enabled rapid tapering of systemic corticosteroids. The patient eventually delivered a healthy male infant at full term. A review of 8 additional PG cases from the literature indicates that dupilumab offers rapid onset of action, facilitates steroid-sparing, and demonstrates a favorable safety profile for both mother and infant. These findings suggest dupilumab as a novel, safe, and effective treatment strategy for refractory pemphigoid gestationis.

Key words: pemphigoid gestationis, dupilumab