中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (7): 480-484.doi: 10.12144/zgmfskin202607480

• 新发与再发感染性皮肤病 • 上一篇    下一篇

昆明市10例HIV合并猴痘流行病学及临床特征分析

窦嘉辰,张艳云,公丽红,徐艳江,瞿文仙,张双梅,李侠,刘恒丽   

  1. 云南省传染病医院，云南昆明，650300
  • 出版日期:2026-07-15 发布日期:2026-06-29

Epidemiological and clinical characteristics of 10 monkeypox cases with HIV in Kunming City

DOU Jiachen, ZHANG Yanyun, GONG Lihong, XU Yanjiang, QU Wenxian, ZHANG Shuangmei, LI Xia, LIU Hengli   

  1. Yunnan Infectious Disease Hospital, Kunming 650300, China
  • Online:2026-07-15 Published:2026-06-29

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摘要： 目的：分析昆明市HIV合并猴痘患者的流行病学及临床特征，为该类患者的临床诊疗提供参考依据。方法：收集2023年8月至2025年12月在云南省传染病医院住院治疗的10例HIV合并猴痘患者的临床资料，对其流行病学史、临床表现、实验室检查、治疗及预后情况进行回顾性分析。结果：10例患者均为男性，中位年龄35.0（31.8, 40.8）岁，其中9例患者发病前21天内有男男性行为史。患者主要临床表现为皮疹和发热，皮疹累及肛门及生殖器区域者占100%，累及颜面部、躯干和四肢者占80%。所有患者均接受抗逆转录病毒治疗（antiretroviral therapy, ART），CD4+T淋巴细胞计数中位数为511.0（359.5, 747.3）个/μL。6例患者梅毒血清学检查阳性，其中2例为现症梅毒感染。结论：昆明市HIV合并猴痘病例以男男性行为人群为主要感染群体，临床表现以皮疹和发热为主，患者梅毒血清学检查阳性率高，临床应加强联合筛查。

关键词: 猴痘, 人类免疫缺陷病毒

Abstract: Objective: To analyze the epidemiological and clinical characteristics of monkeypox cases with HIV in Kunming,and to provide reference for the clinical diagnosis and treatment of such patients. Methods: The clinical data of 10 patients with HIV and concurrent monkeypox infection who were hospitalized at Yunnan Infectious Disease Hospital between August 2023 and December 2025. The epidemiological characteristics, clinical features, laboratory findings, treatment strategies, and clinical outcomes were retrospectively analyzed. Results: All 10 patients were male, with a median age of 35.0 (31.8, 40.8) years. Among them, 9 patients had a history of male-male sexual behavior within 21 days before the onset of the disease. The main clinical manifestations were rashes and fever. Rashes involving the anal and genital areas accounted for 100%, while those involving the face, trunk, and limbs accounted for 80%. All patients received antiretroviral therapy (ART), and the median CD4+T lymphocyte count was 511.0 (359.5,747.3) cells/μL. Syphilis serology was positive in 6 patients, among whom 2 cases were diagnosed with current syphilis infection. Conclusion: Patients with monkeypox and HIV in Kunming mainly consists of MSM. The clinical manifestations are mainly skin rashes and fever. The positivity rate of syphilis serology in patients is high. Clinicians should strengthen combined screening.

Key words: monkeypox, HIV