中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (1): 61-64.doi: 10.12144/zgmfskin202001061

• 综述 • 上一篇    

变应性接触性皮炎的免疫学机制新进展

金莉,曹经江   

  1. 三峡大学附属仁和医院皮肤科，湖北宜昌，443000
  • 出版日期:2020-01-15 发布日期:2020-03-17
  • 通讯作者: 曹经江，E-mail：caojj662008@163.com

Update of immunological mechanism of allergic contact dermatitis

JIN Li, CAO Jingjiang   

  1. Department of Dermatology, Renhe Hospital Affiliated to The Three Gorges University, Yichang 443000, China
  • Online:2020-01-15 Published:2020-03-17
  • Contact: CAO Jingjiang, E-mail: caojj662008@163.com

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摘要： 变应性接触性皮炎（ACD）是常见的T细胞介导的Ⅳ型超敏反应,主要分为三个阶段：致敏期、激发期和消退期。每个阶段所涉及到的细胞和分子作用不尽相同，都有可能成为治疗ACD新的靶点，本文对变应性接触性皮炎的免疫学机制新进展进行了综述。

关键词: 接触性皮炎, 半抗原, 模式识别受体, 树突状细胞, T淋巴细胞

Abstract: Allergic contact dermatitis (ACD) is a common T cell-mediated type IV allergic reaction, which is mainly divided into three stages: sensitizing phase, irritating phase and regression phase. The cellular and molecular effects involved in each stage are different，which may become a new target for the treatment of ACD. The update of immunological mechanism of allergic contact dermatitis is reviewed in this paper.

Key words: contact dermatitis, hapten pattern, recognition receptor, dendritic cells, T lymphocytes