中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (8): 506-509.doi: 10.12144/zgmfskin202108506

• 论著 • 上一篇    下一篇

白芍总苷联合NB-UVB对中重度银屑病血清IL-17、IL-23和皮损PAR-2表达的影响

任国华,赵莹   

  1. 菏泽市立医院皮肤科，山东菏泽，274013
  • 出版日期:2021-08-15 发布日期:2021-07-20
  • 通讯作者: 任国华，E-mail: 279514263@qq.com

Effects of total glucosides of paeony combined with NB-UVB on the expression of serum IL-17, IL-23 and lesion PAR-2 in patients with moderate to severe psoriasis

REN Guohua, ZHAO Ying   

  1. Department of Dermatology, Heze Municipal Hospital, Shandong 274013, China
  • Online:2021-08-15 Published:2021-07-20
  • Contact: REN Guohua, E-mail: 279514263@qq.com

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摘要： 目的：明确白芍总苷联合NB-UVB治疗中重度银屑病的疗效及对血清IL-17、IL-23及皮损蛋白酶活化受体2（PRA-2）表达的影响。方法：选取2019年5月至2020年6月来我院皮肤科就诊的中重度银屑病患者，随机分为NB-UVB组、白芍总苷组、白芍总苷联合NB-UVB组。治疗3个月，计算PASI评分。ELISA法检测各组治疗前后血清IL-17、IL-23水平；免疫组化检测皮损治疗前后PRA-2表达量的变化。结果：共选取90例中重度银屑病患者，每组30例。各组患者治疗前PASI 评分差异无统计学意义（P>0.05）。治疗后，联合治疗组PASI 评分、IL-17和IL-23水平及皮损内角质形成细胞PAR-2染色平均吸光度值均低于NB-UVB组和白芍总苷组（均P<0.05）。结论：白芍总苷联合UVB治疗中重度银屑病疗效优于单用NB-UVB或白芍总苷，其机制可能与血清IL-17、IL-23及皮损PRA-2表达下降有关。

关键词: 白芍总苷, 窄谱中波紫外线, 银屑病, 蛋白酶活化受体2, IL-17, IL-23

Abstract: Objective: To assess the efficacy of total glucosides of paeony combined with NB-UVB in the treatment of moderate to severe psoriasis and detect the level change of serum IL-17, IL-23 and protease activated receptor 2 (PRA-2) in skin lesions. Methods: The patients with moderate to severe psoriasis from May 2019 to June 2020 in our hospital were collected, who were randomly divided into the NB-UVB group, total glucosides group, total glucosides of paeony combined with NB-UVB group. After three-month treatment, the PASI score was calculated. The levels of serum IL-17, IL-23, and PRA-2 expression were detected by ELISA and immunohistochemistry. Results: Ninety patients were collected, 30 in each group. There was no significant difference in PASI scores before treatment in the three groups. After 3-month treatment, the PASI scores, the levels of serum IL-17 and IL-23, and the PRA-2 level were lower in the total glucosides of paeony combined with NB-UVB group than in the group and total glucosides group (Ps<0.05). Conclusion: The treatment of the total glucosides of paeony combined with NB-UVB is more effective than NB-UVB or the total glucosides of paeony. The therapeutic mechanism may be related to the decrease of serum IL-17, IL-23 and PRA-2 expression in skin lesions.

Key words: total glucosides of paeony, narrow-band UV, psoriasis, PRA-2, IL-17, IL-23