二甲双胍,皮肤老化,氧化应激,细胞自噬," /> 二甲双胍,皮肤老化,氧化应激,细胞自噬,"/> metformin, skin aging, oxidative stress, cellular autophagy,"/> <span style="font-size:12px;">二甲双胍抗皮肤老化研究进展</span>

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (2): 150-154.doi: 10.12144/zgmfskin202402150

• 综述 • 上一篇    

二甲双胍抗皮肤老化研究进展

赖惠君1，2,杨岚1,郭红卫1   

  1. 1广东医科大学附属第二医院皮肤病科，广东湛江，524003；
    2广州市红十字会医院，广东广州，510000
  • 出版日期:2024-02-15 发布日期:2024-01-31

Update of metformin in anti-skin aging

LAI Huijun1, 2, YANG Lan1, GUO Hongwei1   

  1. 1 Dermatological Department of The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang 524003, China; 2 Guangzhou Red Cross Hospital, Guangzhou 510000, China
  • Online:2024-02-15 Published:2024-01-31

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摘要： 二甲双胍作为一种口服降糖药物在皮肤抗衰老中表现出潜力，主要通过抑制氧化应激反应、增强细胞自噬功能延缓衰老，降低与年龄相关疾病的发病率和总死亡率。本文就二甲双胍抗皮肤老化研究进展进行综述，为抗衰老药物的研究和开发提供新的思路。

关键词: 二甲双胍')">">二甲双胍, 皮肤老化, 氧化应激, 细胞自噬

Abstract: Metformin, an oral antidiabetic drug, has shown potential in skin anti-aging, primarily through inhibiting oxidative stress reactions, enhancing cellular autophagy function to delay aging, and reducing the incidence and overall mortality of age-related diseases. The paper reviews the anti-aging mechanisms of metformin to provide new insights for the study and development of anti-aging drugs.

Key words: metformin')">">metformin, skin aging, oxidative stress, cellular autophagy