玫瑰痤疮,羟氯喹,唇黏膜,色素沉着," /> 玫瑰痤疮,羟氯喹,唇黏膜,色素沉着,"/> rosacea, hydroxychloroquin, lip mucosal, hyperpigmentation,"/> 口服羟氯喹致唇黏膜色素沉着三例

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (7): 484-487.doi: 10.12144/zgmfskin202407484

• 临床研究 • 上一篇    下一篇

口服羟氯喹致唇黏膜色素沉着三例

吕霜1,2,付希安1,2,施仲香1,2,岳振华1,2,张会敏1,2,刘红1,2,张福仁1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-07-15 发布日期:2024-06-11

Hydroxychloroquine induced lip mucosal hyperpigmentation: three cases report

LYU Shuang1,2, FU Xi'an1,2, SHI Zhongxiang1,2, YUE Zhenhua1,2, ZHANG Huimin1,2, LIU Hong1,2, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2024-07-15 Published:2024-06-11

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摘要： 羟氯喹（HCQ）是一种广泛使用于疟疾和自身免疫疾病的药物，近期也被用于治疗玫瑰痤疮，由于其妊娠安全性，可在女性患者中推广使用。现报道玫瑰痤疮患者口服羟氯喹后出现唇黏膜色素沉着3例，除色素沉着外未见其他不良反应，且经治疗后玫瑰痤疮皮损缓解。停用羟氯喹后，患者唇黏膜色素沉着改善。

关键词: 玫瑰痤疮')">">玫瑰痤疮, 羟氯喹, 唇黏膜, 色素沉着

Abstract: Hydroxychloroquine（HCQ） is a drug widely used to treat malaria and autoimmune diseases, and has recently been used to treat rosacea and could be promoted for use in female patients due to its pregnancy safety. Three cases of lip mucosal hyperpigmentation after oral hydroxychloroquine administration in patients with rosacea is reported, with no adverse effects other than hyperpigmentation, and relief of rosacea lesions after treatment. After discontinuing hydroxychloroquine, a patient' lip mucosal hyperpigmentation slightly decreased. 

Key words: rosacea')">">rosacea, hydroxychloroquin, lip mucosal, hyperpigmentation