抗MDA5抗体,临床无肌病性皮肌炎," /> 抗MDA5抗体,临床无肌病性皮肌炎,"/> anti-MDA5 antibody, clinical amyopathic dermatomyositis,"/> <span style="font-size:12px;">抗MDA5抗体阳性临床无肌病性皮肌炎一例并文献复习</span>

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (7): 494-498.doi: 10.12144/zgmfskin202407494

• 临床研究 • 上一篇    下一篇

抗MDA5抗体阳性临床无肌病性皮肌炎一例并文献复习

米倩1,孟昭影2,杨金良2   

  1. 1河北北方学院研究生院，河北张家口，075000；2河北北方学院附属第一医院，河北张家口，075000
  • 出版日期:2024-07-15 发布日期:2024-06-11

Clinical amyopathic dermatomyositis with anti-MDA5 antibody positive: a case report and literature review

MI Qian1, MENG Zhaoying2, YANG Jinliang2   

  1. 1 Graduate School of Hebei North University, Zhangjiakou 075000, China; 2 The First Affiliated Hospital of Hebei North University, Zhangjiakou 075000, China
  • Online:2024-07-15 Published:2024-06-11

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摘要： 抗MDA5抗体阳性临床无肌病性皮肌炎是一种特殊类型皮肌炎，间质性肺病是其主要肺部并发症，国内少见，本文报道一例并做文献分析。患者，女，67岁。面颈部、肩背部及双手等多处红斑，伴四肢酸痛无力50天。肌炎抗体谱示：抗MDA5抗体IgG（+++），抗SRP抗体IgG（+），抗SSA/Ro-52抗体（+）。胸部CT提示双肺间质纤维化伴感染。结合组织病理学检查，诊断为临床无肌病性皮肌炎（抗MDA5抗体阳性）。

关键词: 抗MDA5抗体')">">抗MDA5抗体, 临床无肌病性皮肌炎

Abstract: Clinical amyopathic dermatomyositis with anti-MDA5 antibody positive is a special type of dermatomyositis. Interstitial lung disease is the main pulmonary complication of this disease, which is rare in China. We reports a case of clinical amyopathic dermatomyositis with anti-MDA5 antibody positive and reviews the literature. A 67-year-old female presented with multiple erythematous plaques on the face and neck, back of the shoulders and hands, with aching and weakness of the limbs for 50 days. Myositis antibody spectrum showed anti-MDA5 antibody IgG(++++), anti-SRP antibody IgG (+), anti-SSA/Ro-52 antibody(+). Chest CT revealed bilateral interstitial lung fibrosis with infection. The diagnosis of clinical amyopathic dermatomyositis (anti-MDA5 antibody-positive) was made.

Key words: anti-MDA5 antibody')">">anti-MDA5 antibody, clinical amyopathic dermatomyositis