阿布昔替尼,皮肤扁平苔藓,JAK抑制剂," /> 阿布昔替尼,皮肤扁平苔藓,JAK抑制剂,"/> abrocitinib, cutaneous lichen planus, JAK inhibitors,"/> 阿布昔替尼治疗皮肤扁平苔藓二例并文献复习

中国麻风皮肤病杂志 ›› 2024, Vol. 40 ›› Issue (6): 412-415.doi: 10.12144/zgmfskin202406412

• 临床研究 • 上一篇    下一篇

阿布昔替尼治疗皮肤扁平苔藓二例并文献复习

崔寅玲1,2,徐凡力1,2,曹珊1,2,薛晓彤1,2,赵晴1,2,刘永霞1,2,刘红1,2,张福仁1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2024-06-15 发布日期:2024-05-07

Abrocitinib in the treatment of cutaneous lichen planus: two cases and literature review

CUI Yinling1,2, XU Fanli1,2, CAO Shan1,2, XUE Xiaotong1,2, ZHAO Qing1,2, LIU Yongxia1,2, LIU Hong1,2, ZHANG Furen1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022,China
  • Online:2024-06-15 Published:2024-05-07

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摘要： 皮肤扁平苔藓的传统治疗包括口服糖皮质激素、甲氨蝶呤、阿维A等药物，常因其不良反应而使用受限。JAK抑制剂通过抑制JAK－STAT通路，影响INF-γ等细胞因子的功能，从而调节免疫。本文报道JAK1抑制剂阿布昔替尼治疗皮肤扁平苔藓2例，并回顾相关文献。

关键词: 阿布昔替尼')">">阿布昔替尼, 皮肤扁平苔藓, JAK抑制剂

Abstract: Conventional treatment of lichen planus includes oral glucocorticosteroids, methotrexate, and Acitretin. The use of these drugs is often limited by their adverse effects. JAK inhibitors regulate immunity by inhibiting the JAK-STAT pathway and affecting the function of cytokines such as INF-γ. In this paper, we report two cases of effective cutaneous lichen planus treated with JAK1 inhibitor abrocitinib and review the relevant literature.

Key words: abrocitinib')">">abrocitinib, cutaneous lichen planus, JAK inhibitors