中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (1): 48-50.doi: 10.12144/zgmfskin202501048

• 临床研究 • 上一篇    下一篇

卡氏枝孢瓶霉感染二例并文献复习

赵安琪1,2，刘佳怡1,2，张雍1,2，刘永霞1,2，于长平1,2，刘红1,2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2025-01-15 发布日期:2024-12-23

Cladophialophora carrionii infection：two cases report and literature review

ZHAO Anqi1,2, LIU Jiayi1,2, ZANG Yong1,2, LIU Yongxia1,2, YU Changping1,2, LIU Hong1,2   

  1. 1 Hospital for Skin Diseases, Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences Department of Dermatology, Jinan 250022, China
  • Online:2025-01-15 Published:2024-12-23

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摘要： 2例患者均为具有外伤史的老年农民，皮损表现为无症状增生性斑块。组织病理学检查示典型的硬壳小体。真菌培养鉴定为卡氏枝孢瓶霉（Cladophialophora carrionii）。给予口服伊曲康唑200 mg每日两次，外用夫西地酸乳膏和硝酸舍他康唑乳膏。1个月后患者皮损改善。本文通过文献复习，发现中国卡氏枝孢瓶霉感染发病人群主要为中老年（平均年龄53.7岁），50%患者有外伤史。受累部位以上肢最为多见，斑块是最常见的皮损形态,平均病程约为 5.4年，由于缺乏自觉症状，患者往往推迟就诊，可能导致感染蔓延，引起畸残。卡氏枝孢瓶霉对抗真菌药物敏感。

关键词: 卡氏枝孢瓶霉, 着色芽生菌病, 真菌感染

Abstract: Both patients were elderly farmers with a history of trauma. The skin lesions presented as asymptomatic proliferative plaques. Histopathological examination showed typical sclerotic bodies. Fungal culture identified the fungal as Cladophialophora carrionii. The patient were treated with oral itraconazole 200 mg twice daily, topical fusidic acid cream and sertaconazole nitrate cream. One month later, the patient's skin lesions improved. We summarized the characters of cases reported in literature, which included Cladophialophora carrionii infection in China were mainly middle-aged and elderly people (mean age 53.7 years), and 50% of the patients had a history of trauma. Upper limbs were the most commonly affected sites, and plaques were the most common manifestation. The average course of disease was about 5.4 years, and due to the lack of subjective symptoms, patients often delay seeking medical advice, which may lead to the spread of infection and disability. Cladophialophora carrionii was sensitive to antifungal drugs.

Key words: Cladophialophora carrionii, chromoblastomycosis, fungal infection