中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (7): 482-485.doi: 10.12144/zgmfskin202507482

• 论著 • 上一篇    下一篇

皮肤血管肉瘤八例临床病理分析

张雪燕1，2,杨宝琦1，2,周桂芝1，2,刘永霞1，2,陈声利1，2   

  1. 1山东第一医科大学附属皮肤病医院，山东济南，250022；2山东省皮肤病性病防治研究所，山东济南，250022
  • 出版日期:2025-07-15 发布日期:2025-07-04

Clinical and pathological analysis of 8 cases with cutaneous angiosarcoma

ZHANG Xueyan1，2, YANG Baoqi1，2, ZHOU Guizhi1，2, LIU Yongxia1，2, CHEN Shengli1，2   

  1. 1 Dermatology Hospital of Shandong First Medical University, Jinan 250022, China; 2 Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2025-07-15 Published:2025-07-04

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摘要： 目的：明确皮肤血管肉瘤（cutaneous angiosarcoma，CAS）的临床病理学特征。方法：收集我院2014-2024年经病理确诊的CAS患者的临床病理资料并进行分析。结果：共纳入8例CAS患者，均为男性，确诊年龄67~91岁，平均78.3岁，发病到确诊时间为1.5~7个月，5例曾被误诊。临床主要表现为红斑、斑块、结节、破溃后出血、结痂。组织病理学主要表现为真皮内见大小不等的血管管腔，部分相互吻合，内皮细胞单层或多层，可向腔内形成乳头状结构，细胞核异型；分化低者管腔不明显，瘤细胞呈梭形，排列成束状。免疫组化示：CD31(+)、CD34部分(+)/(-)、ERG(+)。随访2年3例死亡，2例失访。结论：CAS患者临床表现缺乏特异性，易误诊。病情进展快，预后差。

关键词: 皮肤血管肉瘤, 临床病理, 预后

Abstract: Objective: To investigate the clinical and pathological characteristics of cutaneous angiosarcoma (CAS). Methods: The data of CAS patients in our hospital from 2014 to 2024 were collected and analyzed. Results: A total of 8 patients with CAS were enrolled, all of whom were male. The age at diagnosis ranged from 67 to 91 years old, with an average of 78.3 years old. The time from onset to diagnosis was 1.5-7 months. Five cases had been misdiagnosed. The main clinical manifestations were erythema, plaques, nodules, bleeding after rupture, and scab formation. Histopathology mainly presented as varying sizes of vascular lumens within the dermis, partially overlapping with each other, with a single or multiple layers of endothelial cells that can form papillary structures into the lumen, and nuclear atypia. Those cells with low differentiation had unclear lumens, and tumor cells are spindle shaped and arranged in undles. Immunohistochemical showed CD31(+), CD34 part(+)/(-), ERG(+). During the 2-year follow-up, there were 3 deaths and 2 cases lost to follow-up. Conclusion: The clinical manifestations of CAS patients are lack of specificity and easy to be misdiagnosed. The disease progresses rapidly and the prognosis is poor.

Key words: cutaneous angiosarcoma, clinical pathology, prognosis