中国麻风皮肤病杂志 ›› 2025, Vol. 41 ›› Issue (10): 707-709.doi: 10.12144/zgmfskin202510707

• 新发与再发感染性皮肤病 • 上一篇    下一篇

青岛市12例猴痘患者流行病学及临床特征分析

王红,王兆国,隋建娥,徐光勇   

  1. 青岛市公共卫生临床中心，山东青岛，266033
  • 出版日期:2025-10-15 发布日期:2025-09-26

Epidemiological and clinical characteristics of twelve monkeypox patients in Qingdao

WANG Hong, WANG Zhaoguo, SUI Jian'e, XU Guangyong   

  1. Qingdao Public Health Clinical Center, Qingdao 266033, China
  • Online:2025-10-15 Published:2025-09-26

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摘要： 目的：分析12例住院猴痘感染者的流行病学特征、临床表现及实验室检查，为猴痘的临床诊疗提供参考依据。方法：回顾性分析2023年6月至2024年12月收治于青岛市公共卫生临床中心的12例猴痘患者的流行病学和临床特征。比较合并HIV感染的患者与未感染HIV患者实验室检查结果的差异，统计学分析采用曼惠特尼U检验。结果：12例住院猴痘患者中位年龄为34.50岁，均为男性，均有男男性行为史，8例未婚，7例感染梅毒螺旋体，6例感染HIV，均接受抗反转录病毒治疗(antiretroviral therapy，ART)。发病到住院中位时间为5.50天，中位住院时间为8.50天。患者皮疹主要分布于肛周、四肢、生殖器、躯干。合并HIV感染的猴痘患者的C反应蛋白的平均值高于未感染HIV猴痘患者，但差异均无统计学意义。11例患者预后良好，1例患者面部出现毁容性瘢痕后遗症。结论：青岛地区住院猴痘患者的传播流行均为男男性接触人群，皮疹为主要症状，大部分患者病情较轻，预后好。

关键词: 猴痘, 流行病学, 临床特征

Abstract: Objective: To analyze the epidemiological characteristics, clinical manifestations, and laboratory tests of hospitalized monkeypox infected patients, and provide reference for the clinical diagnosis and treatment of monkeypox. Methods: A retrospective analysis was conducted on the epidemiological and clinical characteristics of 12 monkeypox patients admitted to the Qingdao Public Health Clinical Center from June 2023 to December 2024. The differences in laboratory test results between patients with HIV infection and those without HIV infection were compared, the Mann-Whitney U test was used for statistical analysis. Results: Twelve hospitalized monkeypox patients had a median age of 34.50 years, all of whom were male and had a history of men who have sex with men (MSM). Among them, 8 cases were unmarried, 7 cases were infected with Treponema pallidum, and 6 cases were infected with HIV, all of whom received antiretroviral therapy (ART). The median time from onset to hospitalization was 5.50 days, and the median length of hospital stay was 8.50 days. The patients' skin rashes were mainly distributed in the perianal area, limbs, genitals, and trunk. The average level of C-reactive protein in monkeypox patients with concurrent HIV infection was higher than that in monkeypox patients without HIV infection, but the difference was not statistically significant. Eleven patients had a good prognosis, and one patient had sequelae of disfiguring scars on the face. Conclusion: In Qingdao, the spread and prevalence of hospitalized monkeypox patients are confined to the population of men who have sex with men. Skin rashes are the main symptom, and most patients have mild conditions with a good prognosis.

Key words: monkeypox, epidemiology, clinical characteristics