中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (9): 569-572.

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经表皮水分流失与皮肤屏障的遗传学研究

汪小蒙1 杨森1，2   

  1. 1安徽医科大学第一附属医院，安徽合肥，230000；?2安徽医科大学皮肤病研究所，安徽合肥，230000
  • 出版日期:2018-09-15 发布日期:2018-12-11
  • 通讯作者: 杨森，E-mail：yang2004sen@163.com

Transepidermal water loss and genetics of skin barrier

WANG Xiaomeng1, YANG Sen 1,2   

  1. 1.First Affiliated Hospital of Anhui Medical University, Hefei230000, Anhui, China； 2. Institute of Dermatology, Anhui Medical University, Hefei230000, Anhui, China
  • Online:2018-09-15 Published:2018-12-11
  • Contact: YANG Sen,E-mail：yang2004sen@163.com

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摘要： 经表皮水分流失（Transepidermal water loss?，TEWL）测量的是水分从真皮和表皮的水合层向皮肤表面扩散的通量密度，是用于评估皮肤屏障功能的一项成熟无创的方法，最新的一项研究发现TEWL值与9号染色体9q34.3基因突变密切相关，本文总结了TEWL与皮肤屏障功能的遗传学研究进展。

关键词: 皮肤屏障, 经表皮水分流失, 遗传学研究

Abstract: Measurement of transpidermal water loss (TEWL) is to measure the steady-state water vapor flux across the skin to the external environment, with noninvasive method for assessing the integrity of the skin barrier. A new study found that the TEWL value is closely associated to the gene mutation at chromosome 9q34.3. The genetic update of TEWL and skin barrier is reviewed in this article.

Key words: skin barrier, transepidermal water loss?(TEWL), genetics research