中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (10): 626-630.doi: 10.12144/zgmfskin202010626

• 综述 • 上一篇    下一篇

神经酰胺与相关皮肤病的研究进展

刘韵祎,张嘉文,刘子菁,王小燕,刘乙萱,姜沛彧,许阳   

  1. 南京医科大学第一附属医院皮肤科，南京，210029
  • 出版日期:2020-10-15 发布日期:2020-09-24
  • 通讯作者: 许阳, E-mail: cardioos@163.com

Update of the ceramide and related dermatosis

LIU Yunyi, ZHANG Jiawen, LIU Zijing, WANG Xiaoyan, LIU Yixuan, JIANG Peiyu, XU Yang   

  1. Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Online:2020-10-15 Published:2020-09-24
  • Contact: XU Yang, E-mail: cardioos@163.com

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摘要： 神经酰胺（ceramide,Cer）由长链鞘氨醇碱和脂肪酸组成,参与皮肤屏障的构成、调节皮肤免疫及细胞周期、分化与凋亡等过程。神经酰胺的合成代谢异常与多种皮肤疾病相关，如特应性皮炎、银屑病等。本文就神经酰胺与相关皮肤病的研究进展进行综述。

关键词: 神经酰胺, 皮肤屏障, 皮肤病

Abstract: Ceramide (Cer) consist of a long-chain sphingosine or a related long chain base linked to fatty acid. As an important lipid in epidermis, ceramide doesn't only contribute to the formation of skin barrier, but also plays an important role in the regulation of skin immunity, cell cycle, differentiation and apoptosis. The abnormal anabolism of ceramide is related to many skin diseases, such as atopic dermatitis and psoriasis. The update of the ceramide and related dermatosis is reviewed in this paper.

Key words: ceramide, skin barrier, skin diseases