中国麻风皮肤病杂志 ›› 2018, Vol. 34 ›› Issue (8): 468-472.

• 论著 • 上一篇    下一篇

外用苯烯莫德对特应性皮炎样小鼠的治疗作用

兰宇贞1,2 慕彰磊1 赵琰1 孙婧1 张建中1   

  1. 1.北京大学人民医院皮肤科，北京，100044 2.北京大学第三医院皮肤科，北京，100191
  • 出版日期:2018-08-15 发布日期:2018-12-11
  • 通讯作者: 张建中，E-mail：rmzjz@126.com

Therapeutic effects of topical benvitimod in atopic dermatitis-like murine model

LAN Yuzhen 1,2 ，MU Zhanglei 1，ZHAO Yan 1，ZHANG Jianzhong 1   

  1. 1.Department of Dermtology, Peking University People’s Hospital, Beijing 100044, China；2. Department of Dermtology, Peking University Third Hospital, Beijing100191,China
  • Online:2018-08-15 Published:2018-12-11
  • Contact: ZHANG Jianzhong，E-mail：rmzjz@126. com

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摘要： 目的：评价外用苯烯莫德对卡泊三醇（MC903）诱导的特应性皮炎小鼠模型的治疗作用。方法：36只BALB/c小鼠，6只作为空白对照，30只给予MC903诱导特应性皮炎后再随机分为基质组、0.5%苯烯莫德组、1.0%苯烯莫德组、0.1%糠酸莫米松组和0.1%他克莫司组，治疗前后测量皮肤厚度、经皮水丢失（TEWL）、皮损内CD4+T细胞、胸腺基质淋巴细胞生成素（TSLP）蛋白表达。结果：0.5%和1.0%苯烯莫德乳膏组皮损评分、耳部皮肤厚度、TEWL、皮损内CD4+T细胞及TSLP蛋白水平较基质组均显著降低（P<0.05），1.0%苯烯莫德组疗效优于0.5%苯烯莫德组和他克莫司组（P<0.05），与糠酸莫米松组差异无显著性（P>0.05）。结论：外用苯烯莫德乳膏可减轻特应性皮炎样小鼠局部炎症反应。

关键词: 特应性皮炎, 苯烯莫德, 小鼠模型

Abstract: Objective: To assess the therapeutic effects of topical benvitimod in AD-like murine models induced by calcipotriol (MC903). Methods: Of 36 AD BALB/c murine models, 6 were as normal controls and 30 were induced by MC903, and then, were divided into 5 groups: matrix group, 0.5% benzymoid group, 1.0% benzymoid group, 0.1% mometasone furoate group and 0.1% tacrolimus group (6 mice in each group). The levels of lesion’s thickness and TEWL,CD4+T cells and TSLP protein in the lesions were assessed before and after treatment. Results: After treatment, the levels of dermatitis score, lesion’s thickness, TEWL, CD4+T cells and TSLP in 0.5% and 1.0% benvitimod group were lower than those in the matrix group (Ps<0.05). 1.0% benvitimod was more effective than 0.5% benzymoid and tarcrolimus. The efficacy of 1.0% benvitimod was equivalent?to 0.1% mometasone furoate (P>0.05). Conclusion: Topical benvitimod can improve AD-like symptoms in BALB/c murine models.

Key words: atopic dermatitis, benvitimod, murine model