中国麻风皮肤病杂志 ›› 2026, Vol. 42 ›› Issue (7): 524-526.doi: 10.12144/zgmfskin202607524

• 病例报告 • 上一篇    下一篇

以皮肤损害为首发表现的嗜酸性肉芽肿性多血管炎一例

张元斌,李靖欢,艾东方,冯世军   

  1. 河北医科大学附属沧州市中心医院皮肤科，河北沧州，061000
  • 出版日期:2026-07-15 发布日期:2026-06-29

Eosinophilic granulomatosis with polyangiitis presenting with initial skin lesions: a case report

ZHANG Yuanbin, LI Jinghuan, AI Dongfang, FENG Shijun   

  1. Department of Dermatology, Cangzhou Central Hospital, Hebei Medical University, Cangzhou 061000, China
  • Online:2026-07-15 Published:2026-06-29

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摘要： 嗜酸性肉芽肿性多血管炎（eosinophilic granulomatosis with polyangiitis,EGPA），是一种罕见的系统性坏死性血管炎，临床表现呈高度异质性，仅14%左右的患者以皮肤损害为首发表现。本文报道一例以皮肤损害首发且合并抗GBM抗体阳性的EGPA患者。

关键词: 嗜酸性肉芽肿性多血管炎, 皮肤首发, 紫癜, 嗜酸性粒细胞, 抗GBM抗体

Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic necrotizing vasculitis with highly heterogeneous clinical manifestations, and only about 14% of patients present with skin lesions as the initial symptom. This paper reports a case of EGPA with skin lesions as the initial manifestation and positive anti-glomerular basement membrane (anti-GBM) antibodies.

Key words: eosinophilic granulomatosis with polyangiitis, skin onset, purpura, eosinophil, anti-GBM antibody