中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (10): 644-646.doi: 10.12144/zgmfskin202110644

• 临床研究 • 上一篇    下一篇

血液灌流对腹型过敏性紫癜患儿氧化应激及临床疗效的影响

黄顺,于洋,吴娴婕,林强   

  1. 海南医学院第二附属医院（东湖院区）儿科，海南海口，570100
  • 出版日期:2021-10-25 发布日期:2021-08-31
  • 通讯作者: 黄顺，E-mail: huangjun139@163.com

Effect of hemoperfusion on oxidative stress and efficacy in children with abdominal Henoch-Schonlein purpura

HUANG Shun, YU Yang, WU Xianjie, LIN Qiang   

  1. Department of Pediatrics, Second Affiliated Hospital of Hainan Medical College (Donghu District), Haikou 570100, China
  • Online:2021-10-25 Published:2021-08-31
  • Contact: HUANG Shun, E-mail: huangjun139@163.com

PDF (PC)

184

摘要： 目的：明确血液灌流对重症腹型过敏性紫癜（HSP）患儿氧化应激的影响，并分析其临床疗效。方法：选择2018年2月到2020年2月我院接受治疗的重症腹型HSP患儿作为研究对象。将患儿随机分为对照组和观察组。对照组给予糖皮质激素治疗，观察组在对照组基础上给予血液灌流。检测超氧化物歧化酶（SOD）、丙二醛（MDA）、肿瘤坏死因子-α（TNF-α）和白细胞介素6（IL-6）表达。结果：共收集104例患者，每组52例。观察组腹痛、血便、皮疹消失时间和住院时间分别为（3.62±0.57）d、（5.13±0.72）d、（4.53±0.64）d和（16.37±1.85）d，均显著短于对照组的（5.32±0.84）d、（7.37±1.16）d、（6.65±1.04）d和（19.34±2.26）d（P<0.01）。治疗后观察组SOD显著高于对照组（P<0.01），MDA、TNF-α和IL-6显著低于对照组（P<0.01）。观察组临床治疗总有效率为92.3%，显著高于对照组80.8%（P<0.05）。结论：血液灌流可以显著降低重症腹型过敏性紫癜患儿氧化应激炎症反应，可增强糖皮质激素治疗的疗效。

关键词: 血液灌流, 重症腹型过敏性紫癜, 儿童, 氧化应激, 炎症反应

Abstract: Objective: To determine the effect of hemoperfusion on oxidative stress in children with abdominal Henoch-Schonlein purpura (HSP) and its clinic effects. Methods: The abdominal HSP children were enrolled from January 2020 to January 2021 in our hospital. The patients were divided into the control group and observation group. All the patients were given glucocorticoid, and the patients in the observation group were given additional hemoperfusion. Superoxide dismutase (SOD), malondialdehyde (MDA), TNF-α and IL-6 were detected. Results: A total of 104 cases were collected with 52 in each group. The disappearance time of abdominal pain, bloody stool, rash and hospitalization time in observation group were 3.62±0.57 d, 5.13±0.72 d, 4.53±0.64 d and 16.37±1.85 d respectively, which was shorter than those in control group (5.32±0.84 d, 7.37±1.16 d, 6.65±1.04 d and 19.34±2.26 d,P<0.01). After treatment, the SOD of observation group was significantly higher than that in control group (P<0.01), and MDA, TNF-α, and IL-6 was significantly lower than that in control group (P<0.01). The efficiency rate in observation group was 92.3%, which was significantly higher than that of 80.8% in control group (P<0.05). Conclusion: Hemoperfusion can significantly reduce the oxidative stress and inflammatory reaction of children with severe abdominal HSP, with significant efficacy.

Key words: hemoperfusion, severe abdominal Henoch-Schonlein purpura, children, oxidative stress, inflammatory response