中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (9): 561-564.doi: 10.12144/zgmfskin202109561

• 论著 • 上一篇    下一篇

75例儿童重症药疹临床分析

何振丹,肖异珠   

  1. 重庆医科大学附属儿童医院皮肤科，国家儿童健康与疾病临床医学研究中心，儿童发育疾病研究教育部重点实验室，儿科学重庆市重点实验室，重庆，400014
  • 出版日期:2021-09-15 发布日期:2021-08-04
  • 通讯作者: 肖异珠，E-mail: yizhuxiao@sina.com

Clinic analysis of 75 chiliren with severe drug eruption

HE Zhendan, XIAO Yizhu   

  1. Department of Dermatology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China
  • Online:2021-09-15 Published:2021-08-04
  • Contact: XIAO Yizhu, E-mail: yizhuxiao@sina.com

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摘要：

目的：分析我院儿童重症药疹的临床特点。方法：对我院75例儿童重症药疹患者临床资料进行回顾性分析。结果：75例患儿发病年龄0~17岁，其中婴儿期13例（17.33%），1~3岁11例（14.67%），3~6岁13例（17.33%），6~12岁33例（44.00%），12~18岁5例（6.67%）；SJS 44例（58.60%），DHS 20例（26.60%），TEN 11例（14.60%）。常见致敏药物为抗生素类（33例，44.00%），解热镇痛类（14例，18.67%），抗癫痫类（13例，17.33%）。结论：我院儿童重症药疹主要致敏药物为抗生素类，好发年龄为6~12岁，最常见的类型为SJS。

关键词: 儿童, 重症药疹, 肿瘤坏死因子抑制剂

Abstract: Objective: To analyze clinic characteristic of children with severe drug eruption in our hospital. Methods: The data of 75 children with severe drug eruption in our hospital were analyzed retrospectively. Results: The age of onset of 75 patients was from 3 months to 17 years. Of 75 patients, 13 (17.33%) were younger than 1 year old, 11 (14.67%) aged from 1 to 3 years, 13 (17.33%) aged from 3 to 6 years, 33 (44.00%) aged from 6 to 12 year, 5 (6.67%) aged from 12 to 18 year. The type of severe drug eruption included SJS in 44 patients (58.6%), DHS in 20 patients (26.6%), TEN in 11 patients (14.6%). The common sensitizing drugs were antibiotics in 33 patients (44.00%), antipyretic and analgesic drugs in 14 patients (18.67%), antiepileptic drugs in 13 patients (17.33%). Conclusion: Antibiotics is the most sensitizing drugs for severe drug eruption in children, the peak age is from 6 to 12 years, and the most common tyoe was SJS.

Key words: children, severe drug eruption, tumor necrosis factor inhibitor