中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (10): 595-597.

• 论著 • 上一篇    下一篇

136例慢性荨麻疹自体血清皮肤试验及实验室检测

李萌萌，郭在培，黎静宜，谢小琴，秦沙，余瀅艳，陈双瑜   

  1. 四川大学华西医院皮肤性病科，四川成都，610041
  • 出版日期:2016-10-15 发布日期:2018-12-17
  • 通讯作者: 郭在培， E-mail: guozp930@163.com

Autologous serum skin test and some laboratory tests analysis in 136 patients with chronic urticaria

LI Mengmeng, GUO Zaipei, LI Jingyi,　XIE Xiaoqin, QIN Sha, YU Yingyan, CHEN Shuangyu   

  1. Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China
  • Online:2016-10-15 Published:2018-12-17
  • Contact: GUO Zaipei, E-mail: guozp930@163.com

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摘要： 目的：分析自体血清皮肤试验（ASST）及部分实验室检查指标与慢性荨麻疹（CSU）临床严重性？的相关性。方法：收集136 例CSU患者的临床资料，并进行ASST、血清总IgE、血浆D-二聚体、甲状腺功能及甲状腺抗体检测。结果：136例患者中总IgE升高37例，ASST阳性54例（39.7%），其中ASST阳性患者病程45.27±65.67个月，明显长于ASST阴性患者的35.24±42.54个月（P＜0.01）。血浆D-二聚体升高49例（36%），且与活动度评分（英文全称UAS）成正相关（P＜0.01, r=0.469）。患者抗甲状腺球蛋白抗体阳性24例(17.6%)；甲状腺过氧化物酶抗体阳性14例(10.6%)。25例甲状腺功能异常患者中有9例ASST阳性。结论：ASST、血浆D-二聚体与CSU患者病情相关，而血清总IgE水平与病情无关。

关键词: 慢性自发性荨麻疹, 自体血清皮肤试验, 血浆D-二聚体

Abstract: Objective: To correlate autologous serum skin test (ASST) and some laboratory tests with clinical severity of chronic spontaneous urticaria (CSU). Methods: Clinical data of 136 patients with CSU were collected, and ASST, serum total IgE, plasma D-dimer, thyroid function and autoantibody detection were performed. Results: Out of the 136 patients, serum total IgE was elevated in 37 patients. ASST was positive in 54 (39.7%). The mean duration of CSU was significantly longer in the ASST-positive patients (45.27±65.67 months) than in ASST-negative patients (35.24±42.54 months) (P＜0.01). Plasma D-dimer was elevated in 49(36%), which was correlated with ？UAS (P＜0.01, r=0.469). Antithyroglobulin antibody was positive in 24 patients (17.6%) and antithyroperoxidase antibody was positive in 14 (10.6%). Twienty-five patients had thyroid dysfunction (9 of them were positive for ASST). Conclusion: Our study shows that the severity of CSU is correlated with ASST and plasma D-dimer level, but not serum total IgE.

Key words: chronic spontaneous urticaria, autologous serum skin test, plasma D-dimer