中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (4): 210-213.doi: 10.12144/zgmfskin202004210

• 论著 • 上一篇    下一篇

178例急性自发性荨麻疹转归为慢性的危险因素回顾性分析

孙艳茹1,刘文博1,范梦娇1,张凤杰1,王振华2   

  1. 1潍坊医学院临床学院，山东潍坊，261053；2潍坊市人民医院皮肤科，山东潍坊，261041
  • 出版日期:2020-04-15 发布日期:2020-04-26
  • 通讯作者: 王振华，E-mail: wfzcwzh＠126.com

Retrospective analysis of risk factors for acute spontaneous urticaria developing into chronic spontaneous urticaria in 178 patients

SUN Yanru1， LIU Wenbo1， FAN Mengjiao1， ZHANG Fengjie1, WANG Zhenhua2   

  1. 1 Clinical College of Weifang Medical University, Weifang 261053, China; 2 Department of Dermatology, Weifang People's Hospital, Weifang 261041, China
  • Online:2020-04-15 Published:2020-04-26
  • Contact: WANG Zhenhua, E-mail: wfzcwzh＠126.com

PDF (PC)

79

摘要： 目的：分析影响急性自发性荨麻疹（ASU）转归为慢性自发性荨麻疹（CSU）的危险因素。方法：回顾性分析本院2018年11月至2019年10月178例ASU患者的人口学信息、发病季节、初发病程、自诉可疑过敏原、自体血清皮肤试验（ASST）、7日荨麻疹活动度评分（UAS7）、血常规、血清总IgE测定、治疗药物，Logistic回归分析ASU转归为CSU的危险因素。结果：178例ASU中42例（23.60%）转归为CSU,单因素分析自诉食物过敏（P<0.001）、 ASST试验阳性（P<0.001）、初发病程（P＜0.001）与ASU患者转归为CSU具有相关性；多因素Logistics回归分析示自诉食物过敏（P=0.029）、ASST试验阳性（P=0.043）、初发病程长（P＜0.001）均是影响ASU转归为CSU的独立危险因素。结论：食物过敏、ASST试验阳性、初发病程长是ASU患者转归为CSU的危险因素。

关键词: 急性自发性荨麻疹, 慢性自发性荨麻疹, 危险因素

Abstract: Objective: To analyze the risk factors of acute spontaneous urticaria (ASU) developing into chronic spontaneous urticaria (CSU) in 178 patients. Methods: The data of 178 patients with ASU in Weifang People's Hospital from November 2018 to October 2019 was analyzed, including age, sex, first onset season and duration, self-report of suspected allergens, autologous serum skin test (ASST), urticaria activity score 7 (UAS7), blood routine test, serum total IgE level and therapeutic drugs. Results: Of 178 patients with ASU, 42 (23.60%) developed into CSU. The univariate analysis showed food allergy (P<0.001), positivity for ASST (P<0.001) and long first onset duration (P<0.001) were associated with ASU developing into CSU. Logistic regression analysis showed that food allergy (P=0.029), positivity ASST result (P<0.043) and long first onset duration (P<0.001) were risk factors for ASU developing into CSU. Conclusion: Food allergy, positivity for ASST and long first onset duration are the risk factors for ASU developing into CSU.

Key words: acute spontaneous urticaria, chronic spontaneous urticaria, risk factors